Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells

• Type: Article in International Scientific Journal
• Date: 2016-09-27

Authors

Angela França (Author) Other; Begoña Pérez-Cabezas (Author) Other; Alexandra Correia (Author) ICBAS; Gerald B. pier (Author) Other; Nuno Cerca (Author) Other; Manuel Vilanova (Author) ICBAS

Journal

Title: Frontiers in Microbiology

Vol. 7

Initial page: 1530

ISSN: 1664-302X

Publisher: Frontiers Media

Indexing

ISI Web of Knowledge - 12 Citations

ISI Web of Science

Scopus - 11 Citations

Pubmed / Medline

Scientific classification

CORDIS: Natural sciences > Biological sciences > Biology > Microbiology

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-00M-40G

DOI: 10.3389/fmicb.2016.01530

Abstract (EN): Staphylococcus epidermidis biofilm formation on indwelling medical devices is frequently associated with the development of chronic infections. Nevertheless, it has been suggested that cells released from these biofilms may induce severe acute infections with bacteraemia as one of its major associated clinical manifestations. However, how biofilm-released cells interact with the host remains unclear. Here, using a murine model of hematogenously disseminated infection, we characterized the interaction of cells released from S. epiderrnidis biofilms with the immune system. Gene expression analysis of mouse splenocytes suggested that biofilm-released cells might be particularly effective at activating inflammatory and antigen presenting cells and inducing cellular apoptosis. Furthermore, biofilm-released cells induced a higher production of pro-inflammatory cytokines, in contrast to mice infected with planktonic cells, even though these had a similar bacterial load in livers and spleens. Overall, these results not only provide insights into the understanding of the role of biofilm-released cells in S. epiderrnidis biofilm-related infections and pathogenesis, but may also help explain the relapsing character of these infections.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12