Transient receptor potential channels in bladder function

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

António Avelino Silva (Author) FMUP; Charrua A. (Author) FMUP; Frias, B (Author) Other; Cruz C.D. (Author) FMUP; Boudes, M (Author) Other; de Ridder, D (Author) Other; Francisco Cruz (Author) FMUP

Journal

Title: Acta Physiologica

Vol. 207 No. 1

Pages: 110-122

ISSN: 1748-1708

Indexing

ISI Web of Knowledge - 35 Citations

Scopus - 36 Citations

Other information

Authenticus ID: P-002-23V

DOI: 10.1111/apha.12021

Abstract (EN): The transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons. The urothelium and some interstitial cells also express several TRP channels. In this review, we describe the expression and the known roles of some members of TRP subfamilies, namely TRPV, TRPM and TRPA, in the urinary bladder. The therapeutic interest of modulating the activity of TRP channels to treat bladder dysfunctions is also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13