Mentha piperita essential oil induces apoptosis in yeast associated with both cytosolic and mitochondrial ROS-mediated damage

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Patricia Ferreira (Autor) Outra; Teresa Cardoso (Autor) Outra; Filipa Ferreira (Autor) Outra; Manuel Fernandes Ferreira (Autor) FCUP; Peter Piper (Autor) Outra; Maria Joao Sousa (Autor) Outra

Revista

Título: FEMS Yeast Research

Vol. 14

Páginas: 1006-1014

ISSN: 1567-1356

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 32 Citações

Scopus - 35 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

CORDIS: Ciências Naturais

Outras Informações

ID Authenticus: P-00A-07R

DOI: 10.1111/1567-1364.12189

Abstract (EN): Mentha piperita (MP), also known as peppermint, is an aromatic and medicinal plant widely used in the food industry, perfumery and cosmetic, pharmacy and traditional medicine. Its essential oil (EO) displays antimicrobial activity against a range of bacteria and fungi. In this study, we found that MP EO lethal cytotoxicity is associated with increased levels of intracellular reactive oxygen species, mitochondrial fragmentation and chromatin condensation, without loss of the plasma membrane integrity, indicative of an apoptotic process. Overexpression of cytosolic catalase and superoxide dismutases reverted the lethal effects of the EO and of its major component menthol. Conversely, deficiency in Sod1p (cytosolic copper-zinc-superoxide dismutase) greatly increased sensitivity to both agents, but deficiency in Sod2p (mitochondrial manganese superoxide dismutase) only induced sensitivity under respiratory growth conditions. Mentha piperita EO increased the frequency of respiratory deficient mutants indicative of damage to the mitochondrial genome, although increase in mitochondrial thiol oxidation does not seem to be involved in the EO toxicity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9