Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Cano, A (Autor) Outra; Sanchez Lopez, E (Autor) Outra; Ettcheto, M (Autor) Outra; Lopez Machado, A (Autor) Outra; Espina, M (Autor) Outra; Souto, EB (Autor) Outra; Galindo, R (Autor) Outra; Camins, A (Autor) Outra; Garcia, ML (Autor) Outra; Turowski, P (Autor) Outra

Revista

Título: Nanomedicine

Vol. 15 Nº 6

Páginas: 1239-1261

ISSN: 1743-5889

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 11 Citações

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00S-9NQ

DOI: 10.2217/nnm-2019-0443

Abstract (EN): Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the blood-brain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in controlled drug-delivery systems and target them to the deepest brain regions. Here, we critically review recent advances in the development of drugs incorporated into PNPs and summarize the molecular changes and functional effects achieved in preclinical models of the most common ND disorders. We also briefly discuss the many challenges remaining to translate these findings and technological advances successfully to current clinical settings.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23