Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2018

Autores

Facioni, MS (Autor) Outra; Soares, J (Autor) Outra; Adinolfi, B (Autor) Outra; Gomes, S (Autor) Outra; Raimundo, L (Autor) Outra; Contini, A (Autor) Outra; Ruffoni, B (Autor) Outra; Azzarà, A (Autor) Outra; Tavanti, A (Autor) Outra; Bertoli, A (Autor) Outra; Pistelli, L (Autor) Outra; Lucilia Saraiva (Autor) FFUP; Scarpato, R (Autor) Outra

Revista

Título: Natural product communications

Vol. 13

Páginas: 1105-1110

ISSN: 1934-578X

Editora: SAGE

Indexação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00P-MA7

Abstract (EN): Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica