Microencapsulation of herbicide MCPA with native β-cyclodextrin and its methyl and hydroxypropyl derivatives: An experimental and theoretical investigation

• Type: Article in International Scientific Journal
• Date: 2014

Authors

garrido, jorge (Author) Other; cagide, fernando (Author) Other; melle-franco, manuel (Author) Other; borges, fernanda (Author) FCUP; garrido, e. manuela (Author) Other

Journal

Title: Journal of Molecular Structure

Vol. 1061

Pages: 76-81

ISSN: 0022-2860

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 24 Citations

Other information

Authenticus ID: P-009-3VE

DOI: 10.1016/j.molstruc.2013.12.067

Abstract (EN): When a pesticide is released into the environment, most of it is lost before it reaches its target. An effective way to reduce environmental losses of pesticides is by using controlled release technology. Microencapsulation becomes a promising technique for the production of controlled release agricultural formulations. In this work, the microencapsulation of chlorophenoxy herbicide MCPA with native β-cyclodextrin and its methyl and hydroxypropyl derivatives was investigated. The phase solubility study showed that both native and β-CD derivatives increased the water solubility of the herbicide and inclusion complexes are formed in a stoichiometric ratio of 1:1. The stability constants describing the extent of formation of the complexes have been determined by phase solubility studies. 1H NMR experiments were also accomplished for the prepared solid systems and the data gathered confirm the formation of the inclusion complexes. 1H NMR data obtained for the MCPA/CDs complexes disclosed noticeable proton shift displacements for OCH2 group and H6 aromatic proton of MCPA provided clear evidence of inclusion complexation process, suggesting that the phenyl moiety of the herbicide was included in the hydrophobic cavity of CDs. Free energy molecular mechanics calculations confirm all these findings. The gathered results can be regarded as an essential step to the development of controlled release agricultural formulations containing herbicide MCPA. © 2014 Elsevier B.V. All rights reserved.

Language: English

Type (Professor's evaluation): Scientific