Pomegranate juice effects on cytochrome P450s expression: In vivo studies

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana Faria (Author) FMUP; Rosario Monteiro (Author) FCNAUP; Isabel Azevedo (Author) Other; Conceicao Calhau (Author) FMUP

Journal

Title: Journal of Medicinal Food

Vol. 10 No. 4

Pages: 643-649

ISSN: 1096-620X

Publisher: Mary Ann Liebert

Indexing

ISI Web of Knowledge - 29 Citations

ISI Web of Science

Scopus - 36 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-62V

DOI: 10.1089/jmf.2007.403

Abstract (EN): Beneficial health effects have recently been claimed for pomegranate juice. In vitro and in vivo studies have demonstrated its anti-atherosclerotic capacity, chemoprevention and chemotherapy of prostate cancer, and antiproliferative, apoptotic, and antioxidant activity, among others. On the other hand, there is a complex interplay between tumor initiation, promotion, and progression and xenobiotic biotranformation. This led us to investigate the effect of pomegranate juice consumption on cytochrome P450 (CYP) activity and expression. For this purpose, male mice consumed this fruit juice for 4 weeks, and pentobarbital-induced sleeping time and total hepatic CYP content, activity, and expression were evaluated. Moreover, the activity of CYP isoform 2E1 and expression of the main CYP isoforms, namely, CYP1A1/2, CYP2E1, and CYP3A, were also assessed. It was found that pomegranate juice consumption decreased total hepatic CYP content as well as the expression of CYP1A2 and CYP3A. Prevention of procarcinogen activation through CYP activity/expression inhibition may be involved in pomegranate juice's effect on tumor initiation, promotion, and progression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7