Pathophysiological role of the renin-angiotensin system in cardiovascular diseases

Actual main focus of interest is the study of mechanisms involved in hypertension, chronic heart failure, diabetic nephropathy, stroke and obesity and the contribution of emergent components of the system: angiotensinogen, AC2/angiotensin (1-7)/Mas, angiotensin (1-9), alamandie in these diseases. We also aim to study the renoprotective mechanisms of blockers of the renin-angiotensin system and the role of adenosine in the modulation of the renin-angiotensin system.

Research Area Coordinator: Manuela Morato | Email: mmorato@ff.up.pt

Relevant publications:


• Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats.
  Patinha D, Afonso J, Sousa T, Morato M, Albino-Teixeira A
  Ups J Med Sci. 119:10-8, 2014
  
  
• Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors.
  Patinha D, Fasching A, Pinho D, Albino-Teixeira A, Morato M, Palm F
  Am J Physiol Renal Physiol. 304:F614-22 2013.
  
  
• Pre- and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade.
  Morato M, Pinho D, Sousa T, Guimarães S, Moura D, Albino-Teixeira A
  Eur J Pharmacol. 531:209-16, 2006.
  
  
• The role of angiotensin II in hypertension due to adenosine receptors blockade.
  Morato M, Sousa T, Guimarães S, Moura D, Albino-Teixeira A
  Eur J Pharmacol. 455:135-41, 2002
  
  
• Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors.
  Sousa T, Morato M, Albino-Teixeira A
  Eur J Pharmacol. 441:99-104, 2002
  
  
• Hypertension due to blockade of adenosine receptors.
  Guimarães S, Morato M, Sousa T, Albino-Teixeira A
  Pharmacol Toxicol. 92:160-2, 2002