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Clicar para expandir a pasta DXs   Descarregar este diretório em ficheiro zip   DXs

Clicar para expandir a pasta PEst-OE/SAU/UI4040/2014    Descarregar este diretório em ficheiro zip   PEst-OE/SAU/UI4040/2014

Clicar para expandir a pasta PTDC/AAG-TEC/0739/2014   Descarregar este diretório em ficheiro zip   PTDC/AAG-TEC/0739/2014

Clicar para expandir a pasta PTDC/MAR-BIO/4694/2014   Descarregar este diretório em ficheiro zip   PTDC/MAR-BIO/4694/2014

Clicar para expandir a pasta PTDC/QEQ-MED/3894/2014   Descarregar este diretório em ficheiro zip   PTDC/QEQ-MED/3894/2014

Clicar para colapsar a pasta PTDC/QEQ-PRS/2406/2014   Descarregar este diretório em ficheiro zip   PTDC/QEQ-PRS/2406/2014

Documento Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines   248KB - 2015/01/28
E. Sousa, A. Paiva, N. Nazareth, L. Gales, A.M. Damas, M.S.J. Nascimento, M. Pinto, Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines, European Journal of Medicinal Chemistry, 44 (2009) 3830-3835.

Documento Chiral HPLC for efficient resolution of enantiomers   1MB - 2015/01/28
Y. Okamoto, T. Ikai, Chiral HPLC for efficient resolution of enantiomers, Chemical Society Reviews, 37 (2008) 2593-2608.

Documento Chiral recognition by enantioselective liquid chromatography: Mechanisms and modern chiral stationary phases   5MB - 2015/01/28
M. Lämmerhofer, Chiral recognition by enantioselective liquid chromatography: Mechanisms and modern chiral stationary phases, Journal of Chromatography A, 1217 (2010) 814-856.

Documento Chiral recognition mechanisms in analytical separation sciences   1MB - 2015/01/28
G.K.E. Scriba, Chiral recognition mechanisms in analytical separation sciences, Chromatographia, 75 (2012) 815-838.

Documento Chiral separations: A review of current topics and trends   448KB - 2015/01/28
T.J. Ward, K.D. Ward, Chiral separations: A review of current topics and trends, Anal. Chem., 84 (2012) 626-635.

Documento Enantiomeric resolution of chiral sulfoxides on polysaccharide phases by HPLC   361KB - 2015/01/28
S.A. Matlin, M.E. Tiritan, Q.B. Cass, D.R. Boyd, Enantiomeric resolution of chiral sulfoxides on polysaccharide phases by HPLC, Chirality, 8 (1996) 147-152.

Documento Enantiomeric Resolution of Kielcorin Derivatives by HPLC on Polysaccharide Stationary Phases Using Multimodal Elution   130KB - 2015/01/28
E.P. Sousa, M.E. Tiritan, R.V. Oliveira, C.M.M. Afonso, Q.B. Cass, M.M.M. Pinto, Enantiomeric Resolution of Kielcorin Derivatives by HPLC on Polysaccharide Stationary Phases Using Multimodal Elution, Chirality, 16 (2004) 279-285.

Documento Enantioresolution of Chiral Derivatives of Xanthones on Different Types of Liquid Chromatography Stationary Phases: A Comparative Study   6MB - 2015/01/28
C. Fernandes, M. Pinto, M.E. Tiritan, Enantioresolution of Chiral Derivatives of Xanthones on Different Types of Liquid Chromatography Stationary Phases: A Comparative Study, Current Chromatography, 1 (2014) 139-150.

Documento Enantioresolution of chiral derivatives of xanthones on (S,S)-Whelk-O1 and l -phenylglycine stationary phases and chiral recognition mechanism by docking approach for (S,S)-Whelk-O1   498KB - 2015/01/28
C. Fernandes, A. Palmeira, A. Santos, M.E. Tiritan, C. Afonso, M.M. Pinto, Enantioresolution of chiral derivatives of xanthones on (S,S)-Whelk-O1 and l -phenylglycine stationary phases and chiral recognition mechanism by docking approach for (S,S)-Whelk-O1, Chirality, 25 (2013) 89-100.

Documento Enantioseparation and chiral recognition mechanism of new chiral derivatives of xanthones on macrocyclic antibiotic stationary phases   1MB - 2015/01/28
C. Fernandes, M.E. Tiritan, Q. Cass, V. Kairys, M.X. Fernandes, M. Pinto, Enantioseparation and chiral recognition mechanism of new chiral derivatives of xanthones on macrocyclic antibiotic stationary phases, Journal of Chromatography A, 1241 (2012) 60-68.

Documento Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: An overview   1MB - 2015/01/28
A.R. Ribeiro, A.S. Maia, Q.B. Cass, M.E. Tiritan, Enantioseparation of chiral pharmaceuticals in biomedical and environmental analyses by liquid chromatography: An overview, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., (2014).

Documento Fases Estacionárias Quirais baseadas em Derivados Xantónicos   1MB - 2015/01/28
M. Pinto, M.E. Tiritan, C. Fernandes, Q. Cass, Fases Estacionárias Quirais baseadas em Derivados Xantónicos, in: Boletim da Propriedade Industrial nº 2011/01/21, Portugal, 2011.

Documento HPLC with carbohydrate carbamate chiral phases: Influence of chiral phase structure on enantioselectivity   435KB - 2015/01/28
S.A. Matlin, M.E. Tiritan, A.J. Crawford, Q.B. Cass, D.R. Boyd, HPLC with carbohydrate carbamate chiral phases: Influence of chiral phase structure on enantioselectivity, Chirality, 6 (1994) 135-140.

Documento Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation   386KB - 2015/01/28
R.A.P. Castanheiro, M.M.M. Pinto, S.M.M. Cravo, D.C.G.A. Pinto, A.M.S. Silva, A. Kijjoa, Improved methodologies for synthesis of prenylated xanthones by microwave irradiation and combination of heterogeneous catalysis (K10 clay) with microwave irradiation, Tetrahedron, 65 (2009) 3848-3857.

Documento Isomeric kielcorins and dihydroxyxanthones: Synthesis, structure elucidation, and inhibitory activities of growth of human cancer cell lines and on the proliferation of human lymphocytes in vitro   182KB - 2015/01/28
E.P. Sousa, A.M.S. Silva, M.M.M. Pinto, M.M. Pedro, F.A.M. Cerqueira, M.S.J. Nascimento, Isomeric kielcorins and dihydroxyxanthones: Synthesis, structure elucidation, and inhibitory activities of growth of human cancer cell lines and on the proliferation of human lymphocytes in vitro, Helvetica Chimica Acta, 85 (2002) 2862-2876.

Documento Multidimensional optimization of promising antitumor xanthone derivatives   2MB - 2015/01/28
C.M.G. Azevedo, C.M.M. Afonso, D. Sousa, R.T. Lima, M. Helena Vasconcelos, M. Pedro, J. Barbosa, A.G. Corrêa, S. Reis, M.M.M. Pinto, Multidimensional optimization of promising antitumor xanthone derivatives, Bioorganic and Medicinal Chemistry, 21 (2013) 2941-2959.

Documento New chiral derivatives of xanthones: Synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines   4MB - 2015/01/28
C. Fernandes, K. Masawang, M.E. Tiritan, E. Sousa, V. De Lima, C. Afonso, H. Bousbaa, W. Sudprasert, M. Pedro, M.M. Pinto, New chiral derivatives of xanthones: Synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines, Bioorganic and Medicinal Chemistry, 22 (2014) 1049-1062.

Documento Nuclear magnetic resonance approaches to the rationalization of chromatographic enantiorecognition processes   895KB - 2015/01/28
G. Uccello-Barretta, L. Vanni, F. Balzano, Nuclear magnetic resonance approaches to the rationalization of chromatographic enantiorecognition processes, J. Chromatogr. A, 1217 (2010) 928-940.

Documento P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity   1MB - 2015/01/28
R. Silva, A. Palmeira, H. Carmo, D.J. Barbosa, M. Gameiro, A. Gomes, A.M. Paiva, E. Sousa, M. Pinto, M.D.L. Bastos, F. Remião, P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity, Arch. Toxicol., (2014).

Documento Rational optimization of the Whelk-O1 chiral stationary phase using molecular dynamics simulations   789KB - 2015/01/28
C.F. Zhao, S. Diemert, N.M. Cann, Rational optimization of the Whelk-O1 chiral stationary phase using molecular dynamics simulations, Journal of Chromatography A, 1216 (2009) 5968-5978.

Documento Recent applications in chiral high performance liquid chromatography: A review   2MB - 2015/01/28
A. Cavazzini, L. Pasti, A. Massi, N. Marchetti, F. Dondi, Recent applications in chiral high performance liquid chromatography: A review, Anal. Chim. Acta, 706 (2011) 205-222.

Documento Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases   455KB - 2015/01/28
C. Fernandes, P. Brandão, A. Santos, M.E. Tiritan, C. Afonso, Q.B. Cass, M.M. Pinto, Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases, Journal of Chromatography A, 1269 (2012) 143-153.

Documento Routes to xanthones: An update on the synthetic approaches   6MB - 2015/01/28
C.M.G. Azevedo, C.M.M. Afonso, M.M.M. Pinto, Routes to xanthones: An update on the synthetic approaches, Current Organic Chemistry, 16 (2012) 2818-2867.

Documento Simple method for the prediction of the separation of racemates with high-performance liquid chromatography on Whelk-O1 chiral stationary phase   586KB - 2015/01/28
A. Del Rio, J. Gasteiger, Simple method for the prediction of the separation of racemates with high-performance liquid chromatography on Whelk-O1 chiral stationary phase, Journal of Chromatography A, 1185 (2008) 49-58.

Documento Small molecules as chromatographic tools for HPLC enantiomeric resolution: Pirkle-type chiral stationary phases evolution   4MB - 2015/01/28
C. Fernandes, M.E. Tiritan, M. Pinto, Small molecules as chromatographic tools for HPLC enantiomeric resolution: Pirkle-type chiral stationary phases evolution, Chromatographia, 76 (2013) 871-897.

Documento Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve   721KB - 2015/01/28
C. Fernandes, L. Oliveira, M.E. Tiritan, L. Leitao, A. Pozzi, J.B. Noronha-Matos, P. Correia-De-Sá, M.M. Pinto, Synthesis of new chiral xanthone derivatives acting as nerve conduction blockers in the rat sciatic nerve, European Journal of Medicinal Chemistry, 55 (2012) 1-11.

Documento Synthesis of xanthones: An overview   735KB - 2015/01/28
M.E. Sousa, M.M.M. Pinto, Synthesis of xanthones: An overview, Current Medicinal Chemistry, 12 (2005) 2447-2479.

Documento The predicated demise of racemic new molecular entities is an exaggeration   188KB - 2015/01/28
I. Agranat, S.R. Wainschtein, E.Z. Zusman, The predicated demise of racemic new molecular entities is an exaggeration, Nat. Rev. Drug Discov., 11 (2012) 972-973.

Documento The strategy of enantiomer patents of drugs   212KB - 2015/01/28
I. Agranat, S.R. Wainschtein, The strategy of enantiomer patents of drugs, Drug Discovery Today, 15 (2010) 163-170.

Documento Xanthone derivatives: New insights in biological activities   740KB - 2015/01/28
M.M.M. Pinto, M.E. Sousa, M.S.J. Nascimento, Xanthone derivatives: New insights in biological activities, Curr. Med. Chem., 12 (2005) 2517-2538.

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