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Clicar para expandir a pasta DXs   Descarregar este diretório em ficheiro zip   DXs

Clicar para expandir a pasta PEst-OE/SAU/UI4040/2014    Descarregar este diretório em ficheiro zip   PEst-OE/SAU/UI4040/2014

Clicar para expandir a pasta PTDC/AAG-TEC/0739/2014   Descarregar este diretório em ficheiro zip   PTDC/AAG-TEC/0739/2014

Clicar para expandir a pasta PTDC/MAR-BIO/4694/2014   Descarregar este diretório em ficheiro zip   PTDC/MAR-BIO/4694/2014

Clicar para colapsar a pasta PTDC/QEQ-MED/3894/2014   Descarregar este diretório em ficheiro zip   PTDC/QEQ-MED/3894/2014

Documento Allosteric modulation of caspases   3MB - 2015/01/27
Häcker, H.G., Sisay, M.T. and Gütschow, M. (2011) Allosteric modulation of caspases. Pharmacology and Therapeutics, 132, 180-195.

Documento Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway.   270KB - 2015/01/27
Glória, P.M.C., Coutinho, I., Gonçalves, L.M., Baptista, C., Soares, J., Newton, A.S., Moreira, R., Saraiva, L. and Santos, M.M.M. (2011) Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway. European Journal of Medicinal Chemistry, 46, 2141-2146

Documento Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents   596KB - 2015/01/27
Glória, P.M.C., Gut, J., Gonalves, L.M., Rosenthal, P.J., Moreira, R. and Santos, M.M.M. (2011) Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents. Bioorganic and Medicinal Chemistry, 19, 7635-7642.

Documento Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines   248KB - 2015/01/27
Sousa, E., Paiva, A., Nazareth, N., Gales, L., Damas, A.M., Nascimento, M.S.J. and Pinto, M. (2009) Bromoalkoxyxanthones as promising antitumor agents: Synthesis, crystal structure and effect on human tumor cell lines. European Journal of Medicinal Chemistry, 44, 3830-3835.

Documento Cell death targets and potential modulators in alzheimer's disease   373KB - 2015/01/27
Castro, R.E., Santos, M.M.M., Glória, P.M.C., Ribeiro, C.J.A., Ferreira, D.M.S., Xavier, J.M., Moreira, R. and Rodrigues, C.M.P. (2010) Cell death targets and potential modulators in alzheimer's disease. Current Pharmaceutical Design, 16, 2851-2864.

Documento Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound   412KB - 2015/01/27
Peterson, Q.P., Hsu, D.C., Novotny, C.J., West, D.C., Kim, D., Schmit, J.M., Dirikolu, L., Hergenrother, P.J. and Fan, T.M. (2010) Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound. Cancer Research, 70, 7232-7241.

Documento Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones   571KB - 2015/01/27
Palmeira, A., Vasconcelos, M.H., Paiva, A., Fernandes, M.X., Pinto, M. and Sousa, E. (2012) Dual inhibitors of P-glycoprotein and tumor cell growth: (Re)discovering thioxanthones. Biochemical Pharmacology, 83, 57-68.

Documento Elative rates of Michael reactions of 2′-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors   62KB - 2015/01/27
Reddick, J.J., Cheng, J. and Roush, W.R. (2003) Elative rates of Michael reactions of 2′-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors. Organic Letters, 5, 1967-1970.

Documento Flavonoids with an oligopolysulfated moiety: A new class of anticoagulant agents   1MB - 2015/01/27
Correia-Da-Silva, M., Sousa, E., Duarte, B., Marques, F., Carvalho, F., Cunha-Ribeiro, L.M. and Pinto, M.M.M. (2011) Flavonoids with an oligopolysulfated moiety: A new class of anticoagulant agents. Journal of Medicinal Chemistry, 54, 95-106.

Documento Flavonoids with an oligopolysulfated moiety: A new class of anticoagulant agents   1MB - 2015/01/27
Correia-Da-Silva, M., Sousa, E., Duarte, B., Marques, F., Carvalho, F., Cunha-Ribeiro, L.M. and Pinto, M.M.M. (2011) Flavonoids with an oligopolysulfated moiety: A new class of anticoagulant agents. Journal of Medicinal Chemistry, 54, 95-106.

Documento Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone   653KB - 2015/01/27
Palmeira, A., Paiva, A., Sousa, E., Seca, H., Almeida, G.M., Lima, R.T., Fernandes, M.X., Pinto, M. and Vasconcelos, M.H. (2010) Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone. Chemical Biology and Drug Design, 76, 43-58.

Documento Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors   118KB - 2015/01/27
Chu, W., Rothfuss, J., D'Avignon, A., Zeng, C., Zhou, D., Hotchkiss, R.S. and Mach, R.H. (2007) Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors. Journal of Medicinal Chemistry, 50, 3751-3755.

Documento Michael acceptors as cysteine protease inhibitors   225KB - 2015/01/27
Santos, M.M.M. and Moreira, R. (2007) Michael acceptors as cysteine protease inhibitors. Mini-Reviews in Medicinal Chemistry, 7, 1040-1050.

Documento Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents   960KB - 2015/01/27
Santos, D.M., Santos, M.M.M., Viana, R.J.S., Castro, R.E., Moreira, R. and Rodrigues, C.M.P. (2009) Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents. Chemico-Biological Interactions, 180, 175-182.

Documento PH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery   1MB - 2015/01/27
Sousa, C.T., Nunes, C., Proença, M.P., Leitão, D.C., Lima, J.L.F.C., Reis, S., Araújo, J.P. and Lúcio, M. (2012) PH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. Colloids and Surfaces B: Biointerfaces, 94, 288-295.

Documento Polysulfated xanthones: Multipathway development of a new generation of dual anticoagulant/antiplatelet agents   4MB - 2015/01/27
Correia-Da-Silva, M., Sousa, E., Duarte, B., Marques, F., Carvalho, F., Cunha-Ribeiro, L.M. and Pinto, M.M.M. (2011) Polysulfated xanthones: Multipathway development of a new generation of dual anticoagulant/antiplatelet agents. J. Med. Chem., 54, 5373-5384.

Documento Potential of solid lipid nanoparticles in brain targeting   442KB - 2015/01/27
Kaur, I.P., Bhandari, R., Bhandari, S. and Kakkar, V. (2008) Potential of solid lipid nanoparticles in brain targeting. Journal of Controlled Release, 127, 97-109.

Documento Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.   1MB - 2015/01/27
Pereira, C., Lopes-Rodrigues, V., Coutinho, I., Neves, M.P., Lima, R.T., Pinto, M., Cidade, H., Vasconcelos, M.H. and Saraiva, L. (2014) Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays. European Journal of Pharmaceutical Sciences, 54, 8-16.

Documento Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis   1MB - 2015/01/27
Neves, M.P., Cidade, H., Pinto, M., Silva, A.M.S., Gales, L., Damas, A.M., Lima, R.T., Vasconcelos, M.H. and Nascimento, M.D.S.J. (2011) Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. European Journal of Medicinal Chemistry, 46, 2562-2574.

Documento Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models   2MB - 2015/01/27
Azevedo, C.M.G., Afonso, C.M.M., Soares, J.X., Reis, S., Sousa, D., Lima, R.T., Vasconcelos, M.H., Pedro, M., Barbosa, J., Gales, L. et al. (2013) Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models. European Journal of Medicinal Chemistry, 69, 798-816.

Documento p53 and its mutants in tumor cell migration and invasion   1MB - 2015/01/27
Muller, P.A.J., Vousden, K.H. and Norman, J.C. (2011) p53 and its mutants in tumor cell migration and invasion. Journal of Cell Biology, 192, 209-218.

Documento Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability   242KB - 2015/01/27
Miquel, C., Borrini, F., Grandjouan, S., Aupérin, A., Viguier, J., Velasco, V., Duvillard, P., Praz, F. and Sabourin, J.C. (2005) Role of bax mutations in apoptosis in colorectal cancers with microsatellite instability. American Journal of Clinical Pathology, 123, 562-570.

Documento Routes to xanthones: An update on the synthetic approaches   900KB - 2015/01/27
Azevedo, C.M.G., Afonso, C.M.M. and Pinto, M.M.M. (2012) Routes to xanthones: An update on the synthetic approaches. Current Organic Chemistry, 16, 2818-2867.

Documento Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation   803KB - 2015/01/27
Zorn, J.A., Wille, H., Wolan, D.W. and Wells, J.A. (2011) Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. Journal of the American Chemical Society, 133, 19630-19633.

Documento Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy   394KB - 2015/01/27
Putt, K.S., Chen, G.W., Pearson, J.M., Sandhorst, J.S., Hoagland, M.S., Kwon, J.T., Hwang, S.K., Jin, H., Churchwell, M.I., Cho, M.H. et al. (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nature Chemical Biology, 2, 543-550.

Documento Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines   323KB - 2015/01/27
Neves, M.P., Cravo, S., Lima, R.T., Vasconcelos, M.H., Nascimento, M.S.J., Silva, A.M.S., Pinto, M., Cidade, H. and Corrêa, A.G. (2012) Solid-phase synthesis of 2′-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines. Bioorganic and Medicinal Chemistry, 20, 25-33.

Documento Squaric acid: A valuable scaffold for developing antimalarials?    329KB - 2015/01/27
Kumar, S.P., Glória, P.M.C., Gonalves, L.M., Gut, J., Rosenthal, P.J., Moreira, R. and Santos, M.M.M. (2012) Squaric acid: A valuable scaffold for developing antimalarials? MedChemComm, 3, 489-493.

Documento Substrate specificities of caspase family proteases   706KB - 2015/01/27
Talanian, R.V., Quinlan, C., Trautz, S., Hackett, M.C., Mankovich, J.A., Banach, D., Ghayur, T., Brady, K.D. and Wong, W.W. (1997) Substrate specificities of caspase family proteases. Journal of Biological Chemistry, 272, 9677-9682.

Documento Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study   348KB - 2015/01/27
Newton, A.S., Glória, P.M.C., Gonalves, L.M., Dos Santos, D.J.V.A., Moreira, R., Guedes, R.C. and Santos, M.M.M. (2010) Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. European Journal of Medicinal Chemistry, 45, 3858-3863.

Documento Synthesis, antibacterial and antifungal activity of some derivatives of 2-phenyl-chromen-4-one   66KB - 2015/01/27
Alam, S. (2004) Synthesis, antibacterial and antifungal activity of some derivatives of 2-phenyl-chromen-4-one. Journal of Chemical Sciences, 116, 325-331.

Documento Synthesis of a natural chalcone and its prenyl analogs - Evaluation of tumor cell growth-inhibitory activities, and effects on cell cycle and apoptosis   268KB - 2015/01/27
Neves, M.P., Lima, R.T., Choosang, K., Pakkong, P., De São José Nascimento, M., Vasconcelos, M.H., Pinto, M., Silva, A.M.S. and Cidade, H. (2012) Synthesis of a natural chalcone and its prenyl analogs - Evaluation of tumor cell growth-inhibitory activities, and effects on cell cycle and apoptosis. Chemistry and Biodiversity, 9, 1133-1143.

Clicar para expandir a pasta PTDC/QEQ-PRS/2406/2014   Descarregar este diretório em ficheiro zip   PTDC/QEQ-PRS/2406/2014

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