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Clicar para expandir a pasta DXs   Descarregar este diretório em ficheiro zip   DXs

Clicar para expandir a pasta PEst-OE/SAU/UI4040/2014    Descarregar este diretório em ficheiro zip   PEst-OE/SAU/UI4040/2014

Clicar para expandir a pasta PTDC/AAG-TEC/0739/2014   Descarregar este diretório em ficheiro zip   PTDC/AAG-TEC/0739/2014

Clicar para colapsar a pasta PTDC/MAR-BIO/4694/2014   Descarregar este diretório em ficheiro zip   PTDC/MAR-BIO/4694/2014

Documento A importância da quiralidade no desenvolvimento de novos fármacos   17KB - 2017/06/26
C. Fernandes (autor convidado), A importância da quiralidade no desenvolvimento de novos fármacos, Escola de Inverno de Farmácia, 2ª ed, 19-27 January, 2017

Documento Acetylated flavonosides and xanthonosides: synthesis and tumor cell growth inhibitory effect   1MB - 2018/06/27
1. PhD seminar in Pharmaceutical Sciences, Faculty of Pharmacy University of Porto: Ana Rita da Conceição Neves, “Acetylated flavonosides and xanthonosides: synthesis and tumor cell growth inhibitory effect.” 7th July, 2017.

Documento Alpha-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach   2MB - 2015/01/27
Leao, M.; Gomes, S.; Pedraza-Chaverri, J.; Machado, N.; Sousa, E.; Pinto, M.; Inga, A.; Pereira, C.; Saraiva, L. Alpha-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach. J. Nat. Prod. 2013, 76, 774-8.

Documento Aminocarbazole alkaloid derivatives as potential modulators of p53mutants   1MB - 2018/06/27
Solida Long, Nanthicha Thongdee, Joana B. Loureiro, Madalena M. Pinto, Ploenthip Puthongking, Lucília Saraiva, Emília Sousa, for presenting the poster entitled: “Aminocarbazole alkaloid derivatives as potential modulators of p53mutants”, 18th International Conference on Medicinal Chemistry & Targeted Drug Delivery held during December 6-8, 2017, Dallas, USA.

Documento Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis   972KB - 2015/01/27
Gomes, N. M.; Bessa, L. J.; Buttachon, S.; Costa, P. M.; Buaruang, J.; Dethoup, T.; Silva, A. M.; Kijjoa, A. Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis. Mar. drugs 2014, 12, 822-39.

Documento Antifouling properties of nature-inspired synthetic compounds   54KB - 2017/06/26
J. R. Almeida, M. Correia-da-Silva, E. Sousa, M. Pinto, V. Vasconcelos, I. Cunha, “Antifouling properties of nature-inspired synthetic compounds” 18th International Congress on Marine Corrosion and Fouling, Toulon, France, 19-24 June, 2016, PT-S11-1 pp. 206

Documento Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography   332KB - 2015/01/27
Pinto, E.; Afonso, C.; Duarte, S.; Vale-Silva, L.; Costa, E.; Sousa, E.; Pinto, M. Antifungal activity of xanthones: evaluation of their effect on ergosterol biosynthesis by high-performance liquid chromatography. Chem. Biol. Drug Des. 2011, 77, 212-22.

Documento Carboxyxanthone derivatives: synthesis and structure elucidation   23KB - 2017/06/26
J. Ribeiro, Y.Z. Phyo, C. Leite, C. Fernandes, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, “Carboxyxanthone derivatives: synthesis and structure elucidation”, Escola de Inverno de Farmácia, 2nd ed, 19-27 January, 2017

Documento Chalcone derivatives as potential antitumor agents   428KB - 2017/06/26
Carmen Mariana Pimenta Carvalho Machado “Chalcone derivatives as potential antitumor agents” Seminar held in the Master in Pharmaceutical Chemistry, FFUP, Porto, June 2016

Documento Chalcone Derivatives with Potential Antitumor Activity: Synthesis and Antimitotic Activity Evaluation   574KB - 2018/06/27
C.M. Machado, P. Pinto, D. Almeida, P. M. A. Silva, J. Moreira, J. Salvador, M. Pinto, H. Bousbaa, H. Cidade, “Chalcone Derivatives with Potential Antitumor Activity: Synthesis and Antimitotic Activity Evaluation”, 3ª Edição da Escola de Inverno de Farmácia, 7-15th March 2018, Porto, Portugal.

Documento Chalcone Isosteres: Synthesis and Structure Elucidation   336KB - 2017/06/26
C. M. Machado, J. Moreira, A. Bartzoka, H. Cidade, M. Pinto, “Chalcone Isosteres: Synthesis and Structure Elucidation”, IJUP2017 -10th Meeting of Young Researchs of U. Porto, Porto, Portugal, 8-10 February, 2017

Documento Chemistry of the fumiquinazolines and the structurally related alkaloids: from Nature to the lab bench   3MB - 2017/06/26
Submetido (May 2017) - P. Boonpothong, D. Resende, E. Sousa, A. Kijjoa, M. Pinto, "Chemistry of the fumiquinazolines and the structurally related alkaloids: from Nature to the lab bench", submitted to Natural Product Reports.

Documento Chiral Derivatives of Xanthones: Resolution and Determination of Enantiomeric Purity on Different Types of Liquid Chromatography Stationary Phases   2MB - 2017/06/26
C. Fernandes (autor convidado), M.E. Tiritan, M.M.M. Pinto, “Chiral Derivatives of Xanthones: Resolution and Determination of Enantiomeric Purity on Different Types of Liquid Chromatography Stationary Phases”, 2nd Caparica Christmas Conference on Sample Treatment, 5-7 December, 2016

Documento Chiral derivatives of xanthones: synthesis, enantiomeric purity and effect on human tumor cell lines   84KB - 2017/06/26
Maria Leticia Carraro Mestrado em Química Farmacêutica Dissertação: "Chiral derivatives of xanthones: synthesis, enantiomeric purity and effect on human tumor cell lines" Faculdade de Farmácia da Universidade do Porto, 29 de julho de 2016 (concluída).

Documento Chiral Pharmaceuticals   1MB - 2017/06/26
M.E. Tiritan, A.R. Ribeiro, C. Fernandes, M. Pinto, Chiral Pharmaceuticals. In Kirk-Othmer Encyclopedia of Chemical Technology: John Wiley & Sons, Inc., 2016, pp.1-28

Documento Chiral small molecules as P-gP modulators: synthesis and enantioselectivity studies   124KB - 2017/06/26
Ana Catarina Barros Lopes Mestrado em Toxicologia Analítica Clínica e Forense Dissertação: "Chiral small molecules as P-gP modulators: synthesis and enantioselectivity studies" Faculdade de Farmácia da Universidade do Porto, 22 de novembro de 2016 (concluída).

Documento Chiral Stationary Phases Based on Xanthone Derivatives   1MB - 2015/01/27
Pinto, M.M.M.; Tiritan, M.E.; Fernandes, C.S.G.; Cass, Q.B.; Chiral Stationary Phases Based on Xanthone Derivatives, WO 2011/010284 A2 (27.01.2011)

Documento Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate   54KB - 2017/06/26
A. Barbosa, S. Lima, C. Afonso, S. Reis, "Chitosan/Fucoidan pH sensitive nanoparticles for delivery of methotrexate", IJUP-Encontro de Investigação Jovem Universidade do Porto, Porto, Portugal, Fevereiro 2017

Documento Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6   323KB - 2015/01/27
Reis, C.; AV, D. A. C.; Guimaraes, J. T.; Tuna, D.; Braga, A. C.; Pacheco, J. J.; Arosa, F. A.; Salazar, F.; Cardoso, E. M. Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6. Exp. Ther. Med. 2014, 8, 323-327.

Documento Comparative analysis of Candida biofilm quantitation assays   337KB - 2015/01/27
Taff, H. T.; Nett, J. E.; Andes, D. R. Comparative analysis of Candida biofilm quantitation assays. Med. Mycol. 2012, 50, 214-8.

Documento Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis   2MB - 2015/01/27
Kijjoa, A.; Gonzalez, M. J.; Pinto, M. M.; Nascimento, M. S.; Campos, N.; Mondranondra, I. O.; Silva, A. M.; Eaton, G.; Herz, W. Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia merguensis. Planta Med. 2008, 74, 864-6.

Documento Derivados de fungos marinhos candidatos a agentes quimioterápicos   314KB - 2017/06/26
Projecto de investigação Faculdade de Farmácia da Universidade do Porto Departamento de Ciências Químicas LABORATÓRIO DE QUÍMICA ORGÂNICA E FARMACÊUTICA AGENDA FFUP 2016/2017

Documento Derivatives of natural products: synthesis, purification and UV-stability assay   85KB - 2017/06/26
Natalia Manou, “Derivatives of natural products: synthesis, purification and UV-stability assay”, International student under the ERASMUS programme, July, 2016

Documento Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold   1MB - 2017/06/26
D. Pereira, R.T. Lima, A. Palmeira, H. Seca, J. Soares, S. Gomes, L. Raimundo, C. Maciel, M. Pinto, E. Sousa, M.H. Vasconcelos, L. Saraiva, H. Cidade, “Design and synthesis of new inhibitors of p53-MDM2 interaction with a chalcone scaffold”, Arabian J. Chem., Elsevier, Vol. 2016, doi: http://dx.doi.org/10.1016/ j.arabjc.2016.04.015

Documento Development of chiral stationary phases based on small molecules and polymeric derivatives for enantioseparation of chiral drugs   2MB - 2018/06/27
J. Ribeiro, C. Fernandes, M.E. Tiritan, A.M.S. Silva, M.M.M. Pinto, Development of chiral stationary phases based on small molecules and polymeric derivatives for enantioseparation of chiral drugs, Escola de Inverno de Farmácia, 3ª edição, 7-15 March, 2018.

Documento Development of new chiral stationary phases for liquid chromatography based on marine polymers   79KB - 2018/06/27
João Luís Pinto Ribeiro Mestrado em Química Farmacêutica Dissertação: “Development of new chiral stationary phases for liquid chromatography based on marine polymers” Faculdade de Farmácia da Universidade do Porto, 27th October 2017 (concluída).

Documento Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction   852KB - 2015/01/27
Paiva, A. M.; Pinto, R. A.; Teixeira, M.; Barbosa, C. M.; Lima, R. T.; Vasconcelos, M. H.; Sousa, E.; Pinto, M. Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction. Int. J. Pharm. 2013, 454, 394-402.

Documento Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach   1MB - 2015/01/27
Leão, M.; Pereira, C.; Bisio, A.; Ciribilli, Y.; Paiva, A. M.; Machado, N.; Palmeira, A.; Fernandes, M. X.; Sousa, E.; Pinto, M.; Inga, A.; Saraiva, L. Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach. Biochem. Pharmacol. 2013, 85, 1234-1245.

Documento Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.   571KB - 2015/01/27
Palmeira, A.; Vasconcelos, M. H.; Paiva, A.; Fernandes, M. X.; Pinto, M.; Sousa, E. Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones. Biochem. Pharmacol. 2012, 83, 57-68.

Documento Enantioresolution of bioactive compounds on human serum albumin stationary phase   2MB - 2018/06/27
J.P. Carmo, C. Fernandes, M.E. Tiritan, C. Afonso, M.M.M. Pinto, Enantioresolution of bioactive compounds on human serum albumin stationary phase, Escola de Inverno de Farmácia, 3ª edição, 7-15 March, 2018

Documento Enantioresolution of bioactive compounds on human serum albumin stationary phase   2MB - 2018/06/27
J.P. Carmo, C. Fernandes, M.E. Tiritan, C. Afonso, M.M.M. Pinto, Enantioresolution of bioactive compounds on human serum albumin stationary phase, Escola de Inverno de Farmácia, 3ª edição, 7-15 March, 2018

Documento Evaluation of 2′,4′-dihydroxy-3,4,5-trimethoxychalcone as antimitotic agent that induces mitotic catastrophe in MCF-7 breast cancer cells   2MB - 2015/01/27
Masawang, K.; Pedro, M.; Cidade, H.; Reis, R. M.; Neves, M. P.; Corrêa, A. G.; Sudprasert, W.; Bousbaa, H.; Pinto, M. M. Evaluation of 2′,4′-dihydroxy-3,4,5-trimethoxychalcone as antimitotic agent that induces mitotic catastrophe in MCF-7 breast cancer cells. Toxicol. Lett. 2014, 229, 393-401.

Documento First “MeetingPoint Seminar”   308KB - 2017/06/26
First “MeetingPoint Seminar”– “Synthesis of marine bioactive secondary metabolites and analogues”, Porto, Portugal, 31th March, 2017.

Documento HPLC enantioseparation of Tramadol and its metabolites: method validation and application to environmental samples.   134KB - 2017/06/26
Cátia Sofia Rodrigues Silva Mestrado em Controlo de Qualidade Dissertação: “HPLC enantioseparation of Tramadol and its metabolites: method validation and application to environmental samples.” Faculdade de Farmácia da Universidade da Universidade do Porto, 23 de novembro de 2016. Concluída)

Documento Importance of stereochemistry and P-gp modulation in drug development: In vitro studies with chiral thioxanthones   1MB - 2017/06/26
A. Lopes, E. Martins, R. Silva, C. Fernandes, A. Palmeira, F. Remião, M.M.M. Pinto, E. Sousa, “Importance of stereochemistry and P-gp modulation in drug development: In vitro studies with chiral thioxanthones”, XIX National Congress of Biochemistry, Guimarães, Portugal, 8-10 December 2016

Documento Improvement of the inhibitory effect of xanthones on NO production by encapsulation in PLGA nanocapsules   370KB - 2015/01/27
Teixeira, M.; Cerqueira, F.; Barbosa, C. M.; Nascimento, M. S.; Pinto, M. Improvement of the inhibitory effect of xanthones on NO production by encapsulation in PLGA nanocapsules. J. Drug Target 2005, 13, 129-35.

Documento Induced Production of Emericellamides A and B from the Marine-Derived Fungus Emericella sp. in Competing Co-culture   111KB - 2015/01/27
Oh, D.-C.; Kauffman, C. A.; Jensen, P. R.; Fenical, W. Induced Production of Emericellamides A and B from the Marine-Derived Fungus Emericella sp. in Competing Co-culture. J. Nat. Prod. 2007, 70, 515-520.

Documento Macrocyclic glycopeptide antibiotics: application as chiral selectors for enantioseparation of bioactive compounds   2MB - 2018/06/27
Y.Z. Phyo, S. Cravo, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, C. Fernandes, Macrocyclic glycopeptide antibiotics: application as chiral selectors for enantioseparation of bioactive compounds, Escola de Inverno de Farmácia, 3ª edição, 7-15 March, 2018

Documento Marine Biotechnology: A New Vision and Strategy for Europe   2MB - 2015/01/27
Bǿrrensen, T.; Boyen, C.; Dobson, A.; Höfle, M.; Ianora, A.; Jaspars, M.; Kijjoa, A.; Olafsen, J.; Querellou, J.; Rigos, G.; Wijffels, R. Marine Biotechnology: A New Vision and Strategy for Europe. Marine Board-ESF Position Paper 15 2010, 1-91.

Documento Marine natural flavonoids and their synthetic analogs: chemistry and biological activity   403KB - 2017/06/26
Beatriz Torgal Martins “Marine natural flavonoids and their synthetic analogs: chemistry and biological activity” Seminar held in the Master in Pharmaceutical Chemistry, FFUP, Porto, June 2016

Documento Marine Sulfated Steroids   185KB - 2017/06/26
F. Carvalhal, “Marine Sulfated Steroids” Seminar held in the Master in Pharmaceutical Chemistry, FFUP, Porto, 8 June, 2016

Documento Marine xanthones: synthesis and in silico ADME profile   5MB - 2018/06/27
Álvaro F. Magalhães, J. Soares, D. Loureiro, S. Cravo, C. Azevedo, C. Afonso, M. Pinto; “Marine xanthones: synthesis and in silico ADME profile”; 3ª Edição da Escola de Inverno de Farmácia – EIF2018, Porto, March 9, 2018

Documento Multidimensional optimization of promising antitumor xanthone derivatives   2MB - 2015/01/27
Azevedo, C. M. G.; Afonso, C. M. M.; Sousa, D.; Lima, R. T.; Helena Vasconcelos, M.; Pedro, M.; Barbosa, J.; Corrêa, A. G.; Reis, S.; Pinto, M. M. M. Multidimensional optimization of promising antitumor xanthone derivatives. Bioorg. Med. Chem. 2013, 21, 2941-2959.

Documento Nanodelivery systems for Marine Bioactive Compounds   49KB - 2017/06/26
A. Barbosa, S. Lima, C. Afonso, S. Reis, "Nanodelivery systems for Marine Bioactive Compounds", Seminar held in the Master in Pharmaceutical Chemistry, FFUP, Porto, June 2016

Documento Nanotechnology to Improve Bioactive Genistein Efficacy   83KB - 2017/06/26
A. J. Coutinho, C. Afonso, M. Pinto, A. R. Neves, S. Reis, "Nanotechnology to Improve Bioactive Genistein Efficacy", Seminar held in the Master in Pharmaceutical Chemistry, FFUP, Porto, June 2016

Documento New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines.   4MB - 2015/01/27
Fernandes, C.; Masawang, K.; Tiritan, M. E.; Sousa, E.; de Lima, V.; Afonso, C.; Bousbaa, H.; Sudprasert, W.; Pedro, M.; Pinto, M. M. New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines. Bioorg. Med. Chem. 2014, 22, 1049-62.

Documento New chiral stationary phases based on xanthone derivatives for liquid chromatography   2MB - 2017/06/26
C. Fernandes, M.E. Tiritan, S, Cravo, Y. Phyo, A. Kijjoa, A.M.S. Silva, Q.B. Cass, M.M.M. Pinto, “New chiral stationary phases based on xanthone derivatives for liquid chromatography”, Chirality, 2017, DOI: 10.1002/chir.22706

Documento New insights into cancer-related proteins provided by the yeast model   382KB - 2015/01/27
Pereira, C.; Coutinho, I.; Soares, J.; Bessa, C.; Leao, M.; Saraiva, L. New insights into cancer-related proteins provided by the yeast model. FEBS J 2012, 279, 697-712.

Documento Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction   1MB - 2015/01/27
Soares, J.; Pereira, N. A.; Monteiro, A.; Leao, M.; Bessa, C.; Dos Santos, D. J.; Raimundo, L.; Queiroz, G.; Bisio, A.; Inga, A.; Pereira, C.; Santos, M. M.; Saraiva, L. Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction. Eur. J. Pharm. Sci. 2015, 66, 138-147.

Documento Pequenas moléculas do mar: síntese e aplicações como quimioterápicos e antiincrustantes   519KB - 2017/06/26
E. Sousa, “Pequenas moléculas do mar: síntese e aplicações como quimioterápicos e antiincrustantes”, Worshops OCEANUS, OBA 2017 – Oceanus Biotecnologia Azul, CIIMAR, Terminal de Cruzeiros do Porto de Leixões, Matosinhos, Portugal, 16 de março, 2017

Documento pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery   1MB - 2015/01/27
Sousa, C. T.; Nunes, C.; Proenca, M. P.; Leitao, D. C.; Lima, J. L.; Reis, S.; Araujo, J. P.; Lucio, M. pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. Colloids Surf. B. Biointerfaces 2012, 94, 288-95.

Documento Pint of Science   166KB - 2018/06/27
Pint of Science

Documento Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays   1MB - 2015/01/27
Pereira, C.; Lopes-Rodrigues, V.; Coutinho, I.; Neves, M. P.; Lima, R. T.; Pinto, M.; Cidade, H.; Vasconcelos, M. H.; Saraiva, L. Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays. Eur. J. Pharm. Sci. 2014, 54, 8-16.

Documento Prenylchalcones with potent antiproliferative activity targeting p53 pathway: synthesis and biological activity evaluation   338KB - 2018/06/27
P. Brandão, J. B. Loureiro, S. Carvalho, M. H. Hamadou, S. Cravo, J. Moreira, D. Pereira, M. Pinto, L. Saraiva, H. Cidade, “Prenylchalcones with potent antiproliferative activity targeting p53 pathway: synthesis and biological activity evaluation”, 3ª Edição da Escola de Inverno de Farmácia, 7-15th March 2018, Porto, Portugal

Documento Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models   2MB - 2015/01/27
Azevedo, C. M.; Afonso, C. M.; Soares, J. X.; Reis, S.; Sousa, D.; Lima, R. T.; Vasconcelos, M. H.; Pedro, M.; Barbosa, J.; Gales, L.; Pinto, M. M. Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models. Eur. J. Med. Chem. 2013, 69, 798-816.

Documento Relatório Ana Isabel Barbosa   8MB - 2018/06/27
Relatório Ana Isabel Barbosa

Documento Relatório Daniela Loureiro   311KB - 2018/06/27
Relatório Daniela Loureiro

Documento Relatório Diana Ribeiro   116KB - 2018/06/27
Relatório Diana Ribeiro

Documento Relatório Joana Freitas da Silva   167KB - 2018/06/27
Relatório Joana Freitas da Silva

Documento Resolution and determination of enantiomeric purity of chiral derivatives of xanthones using (S,S)-Whelk-O1 stationary phase   337KB - 2017/06/26
M.L. Carraro, M.E. Tiritan, A.M.S. Silva, C. Fernandes, M.M.M. Pinto, “Resolution and determination of enantiomeric purity of chiral derivatives of xanthones using (S,S)-Whelk-O1 stationary phase” (P89). Chirality 2016, Heidelberg, Germany, 24-27 July 2016

Documento Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases   1MB - 2015/01/27
Fernandes, C.; Brandao, P.; Santos, A.; Tiritan, M. E.; Afonso, C.; Cass, Q. B.; Pinto, M. M. Resolution and determination of enantiomeric purity of new chiral derivatives of xanthones using polysaccharide-based stationary phases. J. Chromatogr. A 2012, 1269, 143-53.

Documento Second “MeetingPoint Seminar”   190KB - 2017/06/26
Second “MeetingPoint Seminar”– “Synthesis of marine bioactive secondary metabolites and analogues”, Porto, Portugal, 05th May, 2017

Documento Secondary metabolites from a culture of the fungus Neosartorya pseudofischeri and their in vitro cytostatic activity in human cancer cells   306KB - 2015/01/27
Eamvijarn, A.; Kijjoa, A.; Bruyere, C.; Mathieu, V.; Manoch, L.; Lefranc, F.; Silva, A.; Kiss, R.; Herz, W. Secondary metabolites from a culture of the fungus Neosartorya pseudofischeri and their in vitro cytostatic activity in human cancer cells. Planta Med. 2012, 78, 1767-76.

Documento Síntese de derivados xantónicos quirais de amino ésteres   23KB - 2017/06/26
H.J. Oliveira, V. Barbosa, A.S. Malheiro, S. Dias, M.E. Tiritan, A.M.S. Silva, C. Fernandes, M.M.M. Pinto, Síntese de derivados xantónicos quirais de amino ésteres, Escola de Inverno de Farmácia, 2ª ed, 19-27 January, 2017

Documento Síntese de novos derivados xantónicos quirais carboxilados   106KB - 2017/06/26
Vera Mónica da Silva Barbosa “Síntese de novos derivados xantónicos quirais carboxilados“, Estágio I do 2ºano de Licenciatura em Bioquímica do Instituto Universitário em Ciências da Saúde –CESPU, Setembro, 2016

Documento Strategy for synthesis of chiral derivatives of xanthones in enantiomerically pure form   9KB - 2017/06/26
B. Freitas, C. Fernandes, M.E. Tiritan, A.M.S. Silva, M.M.M. Pinto, “Strategy for synthesis of chiral derivatives of xanthones in enantiomerically pure form”, IJUP 2017, 10th Meeting of Young Researches of University of Porto, 8-10 February, 2017

Documento Strategy for synthesis of enantiomerically pure xanthones - amino acid derivatives   16KB - 2017/06/26
H. Ribeiro, V. Barbosa, A.S. Malheiro, S. Dias, M.E. Tiritan, A.M.S. Silva, C. Fernandes, M.M.M. Pinto, “Strategy for synthesis of enantiomerically pure xanthones - amino acid derivatives”, IJUP 2017, 10th Meeting of Young Researches of University of Porto, 8-10 February, 2017

Documento Studies towards the total synthesis of neofiscalin A, a potent antibacterial agent   204KB - 2018/06/27
Papichaya Boonpothong Mestrado em Química Farmacêutica Dissertação: “Studies towards the total synthesis of neofiscalin A, a potent antibacterial agent” Faculdade de Farmácia da Universidade do Porto, September 2017 (concluída).

Documento Synergistic effects of thioxanthones with oxacillin against Methicillin-Resistant Staphylococcus aureus   2MB - 2015/01/27
Bessa, L. J.; Palmeira, A.; Gomes, A. S.; Vasconcelos, V.; Sousa, E.; Pinto, M.; Costa, P. M. Synergistic effects of thioxanthones with oxacillin against Methicillin-Resistant Staphylococcus aureus. Microb. Drug Resist. 2015, under revision.

Documento Synthesis and structure elucidation of carboxyxanthone derivative   16KB - 2017/06/26
J. Ribeiro, C. Fernandes, M.E. Tiritan, M.M.M. Pinto, ”Synthesis and structure elucidation of carboxyxanthone derivative”, IJUP 2017, 10th Meeting of Young Researches of University of Porto, 8-10 February, 2017

Documento Synthesis, enantiomeric purity evaluation and enantioselectivity study on human tumor cell lines of new chiral derivatives of xanthones   613KB - 2018/06/27
C. Fernandes, M.L. Carraro, M.E. Tiritan, S. Marques, P.M.A. Silva, H. Bousbaa, A.M.S. Silva, M. Pinto, “Synthesis, enantiomeric purity evaluation and enantioselectivity study on human tumor cell lines of new chiral derivatives of xanthones”, EFMC-ASMC'17, Vienna, Austria, 27-31 August 2017, pp. 159.

Documento Synthesis of a Water Soluble Resveratrol Derivative for Skin Care Formulations   2MB - 2017/06/26
C. Confraria, I.F. Almeida, M. Pinto, E. Sousa, M. Correia da Silva, “Synthesis of a Water Soluble Resveratrol Derivative for Skin Care Formulations”, 10th Meeting of Young Researchers of University of Porto, Porto, Portugal, 8-10 February, 2017

Documento Synthesis of analogues of chalcone CPX with potencial antitumor activity   337KB - 2017/06/26
João Miguel Azevedo Miranda Costa, Pharmaceutical Sciences, adviser in the project course entitled “Synthesis of analogues of chalcone CPX with potencial antitumor activity” (September 2015-July 2016)

Documento Synthesis of Bioactive Chalcones and Their Heterocyclic Derivatives as Potential Antitumor Agents   549KB - 2017/06/26
P. Pinto, P.M.A. Silva, S. Marques, J. Costa, J. Moreira, A. Palmeira, M. Pinto, J. Salvador, H. Bousbaa, H. Cidade, “Synthesis of Bioactive Chalcones and Their Heterocyclic Derivatives as Potential Antitumor Agents” IJUP2017 -10th Meeting of Young Researchs of U. Porto, Porto, Portugal, 8-10 February, 2017

Documento Synthesis of Bioactive Natural Flavones and Their Synthetic Analogues   876KB - 2017/06/26
B.T. Martins, D. Pereira, M. Correia da Silva, H. Cidade, M. Pinto, “Synthesis of Bioactive Natural Flavones and Their Synthetic Analogues”, 2ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 19-27 January 2017, P.17 pp 66-67

Documento Synthesis of chiral carboxylated xanthone derivatives   335KB - 2017/06/26
M.E. Tiritan, C. Fernandes, M.L. Carraro, A.M.S. Silva, M.M.M. Pinto. “Synthesis of chiral carboxylated xanthone derivatives” (P90), Chirality 2016, Heidelberg, Germany, 24-27 July 2016

Documento Synthesis of marine natural products   92KB - 2017/06/26
Amadeu da Costa Câmara, “Synthesis of marine natural products”, Scientific Research Project I student under the Integrated Master of Pharmaceutical Sciences, July, 2016

Documento Synthesis of marine xanthones: tracking yicathins B and C   160KB - 2017/06/26
Daniela Loureiro Mestrado em Química Farmacêutica Industrial Dissertação: “Synthesis of marine xanthones: tracking yicathins B and C” Faculdade de Farmácia da Universidade de Coimbra, 20 de outubro de 2016 (concluída)

Documento Synthesis of natural and non-natural sulfated compounds: challenges and opportunities   766KB - 2017/06/26
M. Correia-da-Silva, A.R. Neves, C. Carvalho, A. Câmara, E. Sousa, M. Pinto, “Synthesis of natural and non-natural sulfated compounds: challenges and opportunities” Terceiro Simpósio Ibero-Americano de Química Orgânica, Porto, Portugal, 23-26 September, 2016, PO-18 pp. 82. (awarded with best poster)

Documento Synthesis of new carboxylic chiral derivatives of xanthones inspired on marine xanthones   118KB - 2018/06/27
Hélder João Ribeiro de Oliveira Mestrado em Química Farmacêutica Dissertação: “Synthesis of new carboxylic chiral derivatives of xanthones inspired on marine xanthones” Faculdade de Farmácia da Universidade do Porto, 23th October 2017 (concluída).

Documento Synthesis of new flavonoid glycosides with a triazole Moiety   517KB - 2018/06/27
D. Pereira, M. Correia-da-Silva, B. T. Martins, A. R. Franco, M. Pinto, H. Cidade, “Synthesis of new flavonoid glycosides with a triazole Moiety”, 3ª Edição da Escola de Inverno de Farmácia, 7-15th March 2018, Porto, Portugal.

Documento Synthesis of Potential Bioactive Flavone Derivatives   332KB - 2017/06/26
B.T. Martins, D. Pereira, M. Correia da Silva, H. Cidade, M. Pinto, “Synthesis of Potential Bioactive Flavone Derivatives”, 10th Meeting of Young Researchers of University of Porto, Porto, Portugal, 8-10 February, 2017

Documento Synthesis of Potential Bioactive Heterocyclic Chalcones   665KB - 2017/06/26
1. Antigoni Bartzoka, Superviser of an ERASMUS student, National Kapodistrian University of Athens, School of Pharmacy, Greece, project entitled: “Synthesis of Potential Bioactive Heterocyclic Chalcones” (February 2016 - June 2016)

Documento Synthesis of promising bioactive chalcone derivatives   873KB - 2017/06/26
C.M. Machado, J. Moreira, A. Bartzoka, H. Cidade, M. Pinto, “Synthesis of promising bioactive chalcone derivatives”, 2ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 19-27 January 2017, P.18 pp 67-68

Documento Synthesis of Water Soluble Compounds for Skin Care Formulations   1MB - 2018/06/27
2. Catarina Isabel Lopes Confraria, Pharmaceutical Sciences Project I report: “Synthesis of water soluble derivatives for skin care formulations” - July 2017.

Documento Synthesis of xanthone derivatives: important chemical substrates to obtain bioactive compounds   2MB - 2018/06/27
- C. Leite, P. Barbosa, K. Maslowska, B. Polónia, J. Ribeiro, Y.Z. Phyo, C. Fernandes, M.E. Tiritan, A. Kijjoa, M.M.M. Pinto, Synthesis of xanthone derivatives: important chemical substrates to obtain bioactive compounds, Escola de Inverno de Farmácia, 3ª edição, 7-15 March, 2018

Documento Synthesis of xanthones: An overview   730KB - 2015/01/27
Sousa, M. E.; Pinto, M. M. M. Synthesis of xanthones: An overview. Curr. Med. Chem. 2005, 12, 2447-2479.

Documento Synthesis of 3-(2,3,4,6-tetra-sulfate-O-β-D-glucopyranosyl)xanthone: a potential new anticoagulant compound   394KB - 2018/06/27
F. Carvalhal, M. Correia-da-Silva, E. Sousa, M. Pinto, Synthesis of 3-(2,3,4,6-tetra-sulfate-O-β-D-glucopyranosyl)xanthone: a potential new anticoagulant compound. P. J.2. 3ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, March 7-15, 2018.

Documento Synthesis of 3,4-dihydroxyxanthone derivatives: hit optimization   2MB - 2017/06/26
F. Carvalhal, E. Sousa, A.R. Neves, M. Correia-da-Silva, M. Pinto, “Synthesis of 3,4-dihydroxyxanthone derivatives: hit optimization” 2ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 19-27 January, 2017, P.21 pp.72-73

Documento Synthetic analogues of marine natural flavonoids as antifouling agents: synthesis and biological evaluation   86KB - 2018/06/27
Beatriz Torgal Martins Mestrado em Química Farmacêutica Dissertação: “Synthetic analogues of marine natural flavonoids as antifouling agents: synthesis and biological evaluation” Faculdade de Farmácia da Universidade do Porto, 25th September 2017 (concluída).

Documento Synthetic Strategies for Fiscalin B and Analogues   880KB - 2017/06/26
N. Lopes, S. Long, D. Resende, A. Kijjoa, A. Silva, M. Pinto, E. Sousa, "Synthetic Strategies for Fiscalin B and Analogues", 10th Meeting of Young Researchers of University of Porto (IJUP17), Porto, Portugal, February, 2017, P26

Documento Synthetic Studies Towards Neofiscalin A, a Potent Antibacterial Agent   1MB - 2017/06/26
P. Boonpothong, D. Resende, A. Kijjoa, E. Sousa, M. Pinto, "Synthetic Studies Towards Neofiscalin A, a Potent Antibacterial Agent", 10th Meeting of Young Researchers of University of Porto (IJUP17), Porto, Portugal, February 2017, P28

Documento Total synthesis and structure elucidation of 3-carboxymethoxyxanthone   10KB - 2017/06/26
C. Leite, C. Fernandes, M.E. Tiritan, M. Pinto, “Total synthesis and structure elucidation of 3-carboxymethoxyxanthone”, IJUP 2017, 10th Meeting of Young Researches of University of Porto, Encontro de Investigação Jovem da Universidade do Porto, 8-10 February, 2017

Documento Total Synthesis of (−)-Fumiquinazolines A, B, C, E, H, and I. Approaches to the Synthesis of Fiscalin A   579KB - 2015/01/27
Snider, B. B.; Zeng, H. Total Synthesis of (−)-Fumiquinazolines A, B, C, E, H, and I. Approaches to the Synthesis of Fiscalin A. J. Org. Chem 2003, 68, 545-563.

Documento Towards oral bioavailability of heparin-like anticoagulant molecules   1MB - 2017/06/26
A.R. Neves, M. Correia-da-Silva, E. Sousa, M.M. Pinto, “Towards oral bioavailability of heparin-like anticoagulant molecules”, 2ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 19-27 January 2017, P.20 pp. 71-72

Documento Towards the total synthesis of neofiscalin A, a potent antibacterial agent   86KB - 2017/06/26
S. Long, D. Resende, P. Boonpothong, A. Kijjoa, E. Sousa, M. Pinto, "Towards the total synthesis of neofiscalin A, a potent antibacterial agent", 8th Brazilian Symposium on Medicinal Chemistry, Búzios, Rio de Janeiro, Brazil, November 2016

Documento Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation and Biological Activities   895KB - 2015/01/27
Pinto, M. M. M.; Castanheiro, R. A. P.; Kijjoa, A. Xanthones from Marine-Derived Microorganisms: Isolation, Structure Elucidation and Biological Activities. In Encyclopedia of Analytical Chemistry, John Wiley & Sons, Ltd: 2014.

Documento Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms   260KB - 2015/01/27
Silva, R. D.; Saraiva, L.; Coutinho, I.; Goncalves, J.; Corte-Real, M. Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms. Curr. Pharm. Des. 2012, 18, 2492-500.

Documento 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta   514KB - 2015/01/27
Mhaidat, N. M.; Bouklihacene, M.; Thorne, R. F. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta. Oncol. Lett. 2014, 8, 699-704.

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