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Chronic renal disease - identification of early biomarkers of renal damage, of progression to end stage renal disease; identification of predictive markers of all-cause and cardiovascular mortality in patients on dialysis treatment


The prevalence of CKD is increasing worldwide, and, in Portugal, the number of dialysis patients raised about 25% in the last decade.

The identification of reliable biomarkers of early kidney injury, of progression of the disease, as well as the identification of predictive biomarkers of cardiovascular morbidity and mortality, is an emergent and important area of research in this increasing public health problem.

Our research studies, aim to enhance health information on CKD and the associated cardiovascular risk; to improve prevention and treatment of CKD, by identifying and validate biomarkers for early detection, progression and outcome of CKD; to identify the determinants of cardiovascular morbidity/mortality of CKD and ESRD patients; to support the development of innovative technologies to improve diagnosis, prognosis and self-management of CKD; to improve the biocompatibility of hemodialysis membranes through the preparation of biologic dialysis membranes.

Relevant publications

  • Cell-free DNA as a marker for the outcome of end-stage renal disease patients on hemodialysis.
    Coimbra S, Rocha S, Nascimento H, Valente MJ, Catarino C, Rocha-Pereira P, Sameiro-Faria M, Oliveira JG, Madureira J, Fernandes JC, Miranda V, Belo L, Bronze-da-Rocha E, Santos-Silva A.
    Clinical Kidney J., 2020 (In Press).

  • Doping Polysulfone Membrane with Alpha-tocopherol and Alpha-lipoic Acid to Suppress Oxidative Stress Induced by Hemodialysis Treatment.
    Kohlová M, Amorim CG, Araújo A, Santos-Silva A, Solich P, Montenegro MCBS.
    Macromol. Biosc., 2020 (In Press).

  • Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease – Association with All-Cause Mortality.
    Valente MJ, Rocha S, Coimbra S, Catarino C, Rocha-Pereira P, Bronze-da-Rocha E, Oliveira JG, Madureira J, Fernandes JC, Sameiro-Faria M, Miranda V, Belo L, Santos-Silva A.
    Mediators of Inflammation, Article ID 3295725, 12 pages. 2019
    https://doi.org/10.1155/2019/3295725

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