|Responsible unit:||Laboratory of Applied Chemistry|
|Course/CS Responsible:||MSc in Pharmaceutical Sciences|
|Acronym||No. of Students||Study Plan||Curricular Years||Credits UCN||Credits ECTS||Contact hours||Total Time|
|Maria de La Salette de Freitas Fernandes Hipólito Reis Dias Rodrigues|
|Theoretical and practical :||1,00|
|Maria de La Salette de Freitas Fernandes Hipólito Reis Dias Rodrigues||1,00|
|Marcela Alves Segundo||1,00|
|Theoretical and practical||Totals||6||6,00|
|Maria de La Salette de Freitas Fernandes Hipólito Reis Dias Rodrigues||3,00|
|Marcela Alves Segundo||3,00|
|Célia Maria Pinto Gomes Amorim||6,00|
|Maria de La Salette de Freitas Fernandes Hipólito Reis Dias Rodrigues||14,00|
|Marcela Alves Segundo||4,00|
The aim of this discipline consists of the study of three large areas of physical-chemistry: thermodynamics, kinetics and binary heterogeneous systems. This therefore consists of the study of chemical thermodynamics – presentation of thermodynamic concepts, their chemical application and the study of biochemical thermodynamics – their application in the thermodynamic knowledge and interpretation of biological and microbiological phenomena, their application in the areas of life sciences and biotechnology. In relation to kinetics, this includes not only the study of chemical kinetics and catalysis but also enzymatic kinetics and enzymatic inhibition. Concerning heterogeneous systems, micelle and liposome systems will be studied, with special emphasis on those applicable as drug delivery systems or for the study of distribution, bioavailability and mechanism of action/interaction with biomembranes of drugs.
Students are expected to acquire the following skills:
1) capacity to apply the knowledge acquired in physical-chemistry to other fields of knowledge present in the MSc in Pharmaceutical Sciences
2) ability to apply chemical concepts in determining physical-chemical parameter and in solving practical problems
3) ability to present their arguments and solutions in a scientific and correct way.
Students should have knowledge of subject-matters taught in General and Inorganic Chemistry. Students should also have basic knowledge of Biochemistry.
Unit 1 - Chemical and Biochemical Thermodynamics Concepts and thermodynamic definitions The zero law of thermodynamic The first law of thermodynamic Thermochemistry The second law of thermodynamic Gibbs function Free energy and equilibrium Application of Gibbs function and entropy to biological systems: coupled reactions, phosphate group transfer reactions, and proton transfer reactions. Biochemical Application of thermodynamics: active and passive transport, sodium-potassium pump, thermodynamics of glucose metabolism. Unit 2 – Kinetics Rate of reaction Rate law Reaction mechanisms and rate law Reaction mechanisms based on kinetics and thermodynamics parameters: alkane halogenation and SN1 and SN2 reactions Chemical Catalysis Unit 3- Enzyme kinetics and inhibition Unit 4 – Binary and heterogeneous systems Introduction to binary phase systems Phase diagrams Analytical applications Introduction to heterogeneous systems Definition of heterogeneous systems: micelles, vesicles, liposomes, membranes Importance of studying the interaction of drugs with heterogeneous systems Heterogeneous systems applied to pharmaceutical technology Drug delivery using heterogeneous systems Catalysis using heterogeneous systems Physico-chemical properties influencing the interaction of drugs with heterogeneous systems Methodologies for studying the interaction of drugs with heterogeneous systems as biomimetic models of lipidic membranes
Theoretical classes: 2 hours / week taught with the help of available audiovisuals. Practical classes: 1 hour/week. Resolution of application problems. Laboratory classes: 2 hours / week include experimental work related to the subject-matters taught in the theoretical classes. The tasks are undertaken in group and all experimental observations are register, with further calculus discussed at the end of the semester.
|Frequência das aulas||39,00|
The assiduity in the laboratorial classes is compulsory, as established in the Norms of Evaluation of the FFUP. The presence at the theoretical classes is not mandatory.
This is the weighted average of the laboratorial classification (obtained during the semester as the distributed evalution or obtained in the practical test as part of the final exam), that contributes with 30%, and the written exam, that contributes with 70%. The lab evaluation is quantified (0 to 20) from the students’ performance during the lab classes, from the recording of experimental observations and associated calculus discussed in a class at the end of the semester (70%). The lab evaluation also comprehends answering some questions given in the written exam (30%). Regarding this last component, some points should be clarified:
a) Students with classification lower than 9.5 after the first call for written exam will not be approved. However, they can be approved in the second call for the written exam if a classification higher than 9.5 is obtained in the reevaluation.
b) If students do not attend to the second call for the written exam or if a classification lower than 9.5 is obtained in the reevaluation, they will not be approved. However, they can submit themselves to the practical test of the final exam in the following two years in order to get approval, as they attendance to the lab classes is considered valid under this period.
The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test in the final exam.
The final exam is composed by two parts: Practical test – it comprehends all the subjects within the laboratorial component of this discipline. One of the experimental protocols will be performed, accompanied by the respective report. The classification should be given within 0 and 20. Besides exceptional cases under Law, the practical test will only be available to students that fulfilled the assiduity requirements and had a classification lower than 9.5 in the laboratory evaluation. Written test – it comprehends all the subjects within the discipline program that were taught. The classification should be given within 0 and 20. Students with classification lower than 8.0 are not approved. Students with classification higher than 8.0 are approved as long as the weighted average of the laboratorial and the written test classifications are equal or higher than 10.
The students, who are lawfully allowed to not attend the experimental classes, and hence are not evaluated in a distributed way, will be compulsory expected to perform the practical test and also the oral test in the final exam.
cf. current FFUP Evaluation Rules
The students who wish to improve their own classification can make it through the written test of the final examination.