Pivotal role of microRNAs in cardiac physiology and heart failure

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2013

Autores

Leite Moreira, AM (Autor) FMUP; Andre P Lourenco (Autor) FMUP; Falcao Pires, I (Autor) FMUP; Leite-Moreira AF (Autor) FMUP

Revista

Título: Drug Discovery Today

Vol. 18 Nº 17-18

Páginas: 1243-1249

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 29 Citações

Scopus - 30 Citações

Outras Informações

ID Authenticus: P-008-J33

DOI: 10.1016/j.drudis.2013.07.025

Abstract (EN): Cardiac hypertrophy is a hallmark of heart failure (HF), a highly prevalent, debilitating and deadly condition in Western countries. Pronounced changes in molecular pathways governing cardiac physiology underlie hypertrophy and progression to HF. MicroRNAs, small nucleotide sequences that coordinate gene expression, may have a central role in orchestrating these changes since the hypertrophic and HF myocardium clearly shows disturbed microRNA profiles. Experimental interventions targeting miR disturbances have been shown beneficial in animal models of cardiac hypertrophy and HF. This short review discusses exciting potential diagnostic and therapeutic applications of microRNAs to cardiac hypertrophy and HF, highlighting the underlying molecular pathways.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7