Fermentation Engineering

Code:

EQ0105

Acronym:

EF

Keywords
Classification	Keyword
OFICIAL	Natural Sciences (Biological Sciences)

Instance: 2011/2012 - 1S

Active?	Yes
Responsible unit:	Department of Chemical Engineering
Course/CS Responsible:	Master in Chemical Engineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	15	Syllabus	3	-	6	56	162
MIEQ	11	Syllabus	4	-	6	56	162

Teaching language

Suitable for English-speaking students

Objectives

This course aims to endow students with skills to plan, dimension and analyse operations with cell reactors (microbial in particular) in suspension and cell aggregates (including fixed biomass). This course also aims to acquaint students with the analysis and dimensioning of complementary units of fermention processes.

Program

1. Integration of bio reactors on industrial processes; fermentative processes; general characteristics of microorganisms

2. Cell culture (culture of microbial cells, animals and plants; quantification of cell growing; cell immobilization; microbial film)

3. Material balances (mass balances of one or more components; balances of multiple units; balance of units with recycling, bypass); bioreactors of microbial cells: classification; reactors with suspended and fixed biomass; Bioreactors operation (batch, fed-batch, continuous); equipment characteristics

4. Modelling and simulation of processes in microbial bioreactors: examples; software

5. Agitation and aeration (concept of mass transference; correlation of mass transference coefficient; quantification of interfacial area; absorption rate/oxygen transference; KLa correlation; Hold-up)

6. Sterilisation (sterilisation methods; kinetics of thermal death; discontinuous and continuous sterilization; air sterilization)

7. Scale variation in bioreactors: general concepts

Mandatory literature

Lee J.M. ; Biochemical Engineering. , Prentice-Hall Inc., 2001
Bailey J.E., Ollis D.F. ; Biochemical Engineering Fundamentals. , McGraw-Hill., 1987

Complementary Bibliography

Lopes A.M., Fonseca A. ; Biologia microbiana. , Universidade aberta., 1996
Ferreira W.F.C., de Sousa J.C.F. ; Microbiologia. Volume 1. , Lidel – edições Técnicas, Lda., 1998
Fonseca M.M., Teixeira J.A. ; Reactores biológicos - fundamentos e aplicações, Lidel – edições técnicas, Lda., 2007

Teaching methods and learning activities

This course will be based on the oral presentation of the theoretical themes of the course and methodologies, by using a data show and online material available on the Internet, as well as problem solving and examples.
Students will be asked to solve more complex problems and they might need to use computer programs (such as Microsoft Excel or similar; SuperPro Designer; Berkeley Madonna). It will be given examples of bioreactors dimensioning, where modelling and design rules have to be applied.

Software

Microsoft Windows
Adobe Acrobat
SuperPro Designer

keywords

Natural sciences > Biological sciences > Biological engineering
Technological sciences > Engineering

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
Attendance (estimated)	Participação presencial	56,00
	Total:	-	0,00

Calculation formula of final grade

Final Mark will be calculated as follows:
Final Exam (85% of the final mark)
Continuous assessment (an individual assignment and an oral presentation on fermentation engineering) - 15% of the final mark
Recurso exam

Students have to reach a minimum grade of 9,5 out of 20 to complete the course. However, students have to reach a minimum grade of 8 out of 20 on the final exam.

Special assessment (TE, DA, ...)

Students with a special status have also to do all the assignments and they have to be delivered on time. Therefore, students with a special status will be assessed in the same way as normal students.

Classification improvement

Recurso exam
The grade of the assignments cannot be improved.