Cyclodextrins as excipients in tablet formulations

• Type: Another Publication in an International Scientific Journal
• Date: 2018

Authors

Conceicao, J (Author) Other; Adeoye, O (Author) Other; Cabral Marques, HM (Author) Other; Sousa Lobo JM (Author) FFUP

Journal

Title: Drug Discovery Today

Vol. 23

Pages: 1274-1284

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Other information

Authenticus ID: P-00P-0JZ

DOI: 10.1016/j.drudis.2018.04.009

Abstract (EN): This paper aims to provide a critical review of cyclodextrins as excipients in tablet formulations, highlighting: (i) the principal pharmaceutical applications of cyclodextrins; (ii) the most relevant technological aspects in pharmaceutical formulation development; and (iii) the actual regulatory status of cyclodextrins. Moreover, several illustrative examples are presented. Cyclodextrins can be used as complexing excipients in tablet formulations for low-dose drugs. By contrast, for medium-dose drugs and/or when the complexation efficiency is low, the methods to enhance the complexation efficiency play a key part in reducing the cyclodextrin quantity. In addition, these compounds are used as fillers, disintegrants, binders and multifunctional direct compression excipients of the tablets.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11