Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Mesquita, P (Author) Other; Peixoto, AJ (Author) Other; Seruca, R (Author) FMUP; Hanski, C (Author) Other; Raquel Almeida (Author) Other; Santos-Silva F (Author) Other; Celso Reis (Author) Other; David L (Author) FMUP

Journal

Title: Cancer Letters

Vol. 189

Pages: 129-136

ISSN: 0304-3835

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-000-HZQ

DOI: 10.1016/s0304-3835(02)00549-9

Abstract (EN): In the present work we investigated the methylation levels of mucin gene (MUC)2 promoter region in normal gastric mucosa and mucinous gastric carcinoma in order to access if the observed de novo expression of the intestinal mucin MUC2 in mucinous gastric carcinoma is associated with changes in MUC2 promoter methylation status. The results obtained by methylation-sensitive single nucleotide primer extension suggest that MUC2 expression in gastric cells is regulated by promoter methylation and further indicate that two specific cytosine guaine dinucleotide (CpG) sites may play a particularly important regulatory role.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8