Nickel induces apoptosis in human neutrophils

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Marisa Freitas (Author) Other; Pedro Barcellos de Souza (Author) Other; Christina Barja Fidalgo (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: Biometals

Vol. 26

Pages: 13-21

ISSN: 0966-0844

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 21 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-0VK

DOI: 10.1007/s10534-012-9590-2

Abstract (EN): Nickel is an ubiquitous transition metal that is industrially applied in many forms, which inevitably leads to a high degree of occupational and environmental exposure. Over-exposure to nickel can produce a variety of adverse effects on human health, including allergy and lung and nasal cancers. In the present study, it is demonstrated, for the first time, that nickel [(Ni(II)] (as a nickel nitrate salt) at concentrations that may be attained in vivo, induces neutrophils' apoptosis by the intrinsic pathway. The use of diphenyleneiodonium, a NADPH oxidase inhibitor, delayed Ni(II)-induced apoptosis, suggesting that NADPH oxidase-derived reactive oxygen species and subsequent signaling could contribute to this event. This is an important finding since increased apoptosis mediated by nickel may disrupt the physiological activities of neutrophils, with potential impact in its immunological and antimicrobial role.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9