Flow injection electrochemical determination of apomorphine

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Garrido, JMPJ (Author) Other; Delerue Matos, C (Author) Other; Borges, F (Author) FFUP; Macedo, TRA (Author) Other; Oliveira Brett, AM (Author) Other

Journal

Title: Analytical Letters

Vol. 36

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-J4X

Abstract (EN): Few analytical methods are currently available for determination of apomorphine, the active substance of a new oral formulation used in the treatment of erectile dysfunction. In this way a flow injection electrochemical method (FIA-EC) was developed for its quantification and applied to pharmaceutical dosage forms. Based in previous findings regarding the stability of apomorphine in borate buffer and after optimization of several analytical parameters a single channel flow injection manifold was set up that enables the determination of this drug over the concentration range of 3 to 16 mumol L-1 with a detection limit of 0.5 mumol L-1 at a sampling rate of 90 h(-1). The simplicity and rapidity of the FIA-EC method used, its reproducibility and sensitivity make it suitable for quality control of pharmaceutical preparations of apomorphine intended for clinical use and research.

Language: English

Type (Professor's evaluation): Scientific