New analytical method for the determination of musks in personal care products by Quick, Easy, Cheap, Effective, Rugged, and Safe extraction followed by GC-MS

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Vera Homem (Author) FEUP; José Avelino Silva (Author) FEUP; Carina Cunha (Author) FEUP; Arminda Alves (Author) FEUP; Lúcia Santos (Author) FEUP

Journal

Title: Journal of Separation Science

Vol. 36 No. 13

Pages: 2176-2184

ISSN: 1615-9306

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 26 Citations

Scientific classification

CORDIS: Natural sciences > Environmental science > Ecology > Applied ecology ; Natural sciences > Environmental science > Ecology > Aquatic ecology ; Natural sciences > Environmental science > Ecology > Environmental risks ; Natural sciences > Environmental science > Natural resources management > Environmental protection

FOS: Natural sciences > Chemical sciences

Associated Projects

SAFEPINE - SAFEPINE - Avaliação da contaminação de pinheiros por poluentes emergentes

Other information

Authenticus ID: P-006-9EW

DOI: 10.1002/jssc.201300190

Abstract (EN): Synthetic musks are organic compounds used as fragrance additives and fixative compounds in a diversity of personal care products. A new method based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction followed by GC-MS for the analysis of 12 musks in personal care products was developed and validated. Some experimental parameters, such as total QuEChERS mass, sample mass/solvent volume ratio, type of extraction solvent, as well as salts and sorbents amount were investigated and optimized. The final method involves the musks extraction using acetonitrile, followed by the addition of anhydrous magnesium sulphate and sodium acetate. The clean-up step was performed using dispersive SPE with primary and secondary amine and octadecyl-silica sorbents. This extraction procedure is fast (about 10 min) when compared to other traditional approaches. The method was robust for the matrices studied and shows a high precision (%RSD < 15%) and accuracy (average recovery of 85%), allowing the detection of musks in minimum concentrations between 0.01 ng/g (galaxolide) and 15.80 ng/g (musk xylene). The developed method was applied to the analysis of 12 samples, which revealed musks concentrations ranging from 2 ng/g (toothpaste) to 882 340 ng/g (perfumed body lotion).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9