The use of SLN (R) and NLC (R) as topical particulate carriers for imidazole antifungal agents

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Souto, EB (Author) Other; Muller, RH (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: PHARMAZIE

Vol. 61

Pages: 431-437

ISSN: 0031-7144

Indexing

ISI Web of Knowledge - 59 Citations

Other information

Authenticus ID: P-00K-JD9

Abstract (EN): Two different imidazole antifungal agents have been used as model drugs to be incorporated into solid lipid nanoparticles (SLN (R)) and nanostructured lipid carriers (NLC (R)), once they are very well established as anti-mycotics for the treatment of topical fungal infections. Because of the high mucoadhesive properties and the strong in situ gelling properties of polyacrylic acid polymers, hydrogels prepared with those macromolecules might be a promising vehicle for imidazole-loaded lipid nanoparticles, such as the above-mentioned SLN and NLC. Thus, in this study Carbopol (R) 934 has been selected for the preparation of semi-solid formulations based on SLN and NLC. Formulations have been stored at three different temperatures before and after particle incorporation into polyacrylate hydrogels. The particle size and the chemical stability of incorporated model drugs have been monitored by HPLC analysis for two years. On the day of production 91.7% and 98.7% of clotrimazole, but only 62.1% and 70.3% of ketoconazole have been recovered from SLN and NLC, respectively. More than 95% of clotrimazole but less than 30% of ketoconazole were detected in the developed formulations after a shelf life of two years. Those values showed to be higher than those obtained with reference emulsions of similar composition and droplet sizes. By rheological measurements a pseudoplastic behaviour with thixotropic properties has been characterized for all semi-solid systems.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7