Statistical analysis of neuromuscular blockade response: contributions to an automatic controller calibration

• Type: Article in International Scientific Journal
• Date: 2005

Authors

M. Eduarda Silva (Author) Other; Teresa Mendonça (Author) FCUP; Isabel Silva (Author) FEUP; Hugo Magalhães (Author) Other

Journal

Title: Computational Statistics and Data Analysis

Vol. 49 No. 3

Pages: 955-968

ISSN: 0167-9473

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 5 Citations

ISI Web of Science

Scopus - 6 Citations

INSPEC

Scientific classification

FOS: Natural sciences > Computer and information sciences

CORDIS: Physical sciences > Mathematics > Statistics

Other information

Authenticus ID: P-000-2YZ

DOI: 10.1016/j.csda.2004.05.036

Abstract (EN): Muscle relaxant drugs are currently given during surgical operations. The design of controllers for the automatic control of neuromuscular blockade benefits from an individual tuning of the controller to the characteristics of the patient. A novel approach to the characterization of the neuromuscular blockade response induced by an initial bolus at the beginning of anaesthesia is proposed. This approach is based on the statistical analysis of the data using principal components and Walsh-Fourier spectral analysis. These methods provide information about the patients dynamics, allowing the on-line autocalibration of the controller, using multiple linear regression techniques. Observed and simulated data are used to compare different approaches to the characterization of the bolus response.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14