Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Duarte, JA (Author) FADEUP; Leao, A (Author) Other; Magalhaes, J (Author) FADEUP; Ascensao, A (Author) FADEUP; Bastos, ML (Author) FFUP; Amado, FL (Author) Other; Vilarinho, L (Author) Other; Quelhas, D (Author) Other; Appell, HJ (Author) Other; Carvalho, F (Author) FFUP

Journal

Title: Toxicology

Vol. 206

Pages: 349-358

ISSN: 0300-483X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 17 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-4ZS

DOI: 10.1016/j.tox.2004.07.012

Abstract (EN): The aim of this study was to investigate the influence of ecstasy (MDMA) administration on body temperature and soleus muscle histology in exercised and non-exercised mice. Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10 mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90 min level run at a velocity of 900 m/h, immediately after the MDMA or saline administration. Body temperature was recorded every 30 min via subcutaneous implanted transponder. Animals were sacrificed 1.5, 25.5, and 49.5 h after i.p. injection and the soleus muscles were removed and processed for light and electron microscopy. The MDMA-treated animals showed a significant increase in body temperature (similar in M and M + EX groups), reaching the peak 90 min after i.p. administration; their temperature remained higher than control for more than 5 h. The EX group evidenced a similar and parallel, yet lower temperature increase during exercise and recovery. Morphological signs of damage were rarely encountered in the EX group; they were more pronounced in M group and even aggravated in M + EX group. In conclusion, MDMA and exercise per se increased body temperature but in conjunction did not have a cumulated effect. However, ecstasy and concomitant physical activity might severely accumulate with regard to skeletal muscle toxicity and may lead to rhabdomyolysis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10