Fluorinated Molecules and Nanotechnology: Future 'Avengers' against the Alzheimer's Disease?

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Dabur, M (Author) Other; Joana A Loureiro (Author) FEUP; Maria do Carmo Pereira (Author) FEUP

Journal

Title: International Journal Of Molecular Sciences

Vol. 21

Final page: 2989

ISSN: 1661-6596

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00S-1R5

DOI: 10.3390/ijms21082989

Abstract (EN): Alzheimer's disease (AD) is a serious health concern, affecting millions of people globally, which leads to cognitive impairment, dementia, and inevitable death. There is still no medically accepted treatment for AD. Developing therapeutic treatments for AD is an overwhelming challenge in the medicinal field, as the exact mechanics underlying its devastating symptoms is still not completely understood. Rather than the unknown mechanism of the disease, one of the limiting factors in developing new drugs for AD is the blood-brain barrier (BBB). A combination of nanotechnology with fluorinated molecules is proposed as a promising therapeutic treatment to meet the desired pharmacokinetic/physiochemical properties for crossing the BBB passage. This paper reviews the research conducted on fluorine-containing compounds and fluorinated nanoparticles (NPs) that have been designed and tested for the inhibition of amyloid-beta (A beta) peptide aggregation. Additionally, this study summarizes fluorinated molecules and NPs as promising agents and further future work is encouraged to be effective for the treatment of AD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16