STEM CELLS MECHANICS ON REGENERATIVE PROCEDURES: A PRELIMINARY COMPUTATIONAL STUDY OF THE ACTIN NETWORK ACTIVE BEHAVIOR

• Type: Article in International Conference Proceedings Book
• Date: 2015

Authors

Ferreira, J (Author) Other; Parente, MPL (Author) FEUP; Renato Natal Jorge (Author) FEUP

Conference proceedings International

Title: Proceedings of the 6th International Conference on Mechanics and Materials in Design - M2D2015

Pages: 1815-1816

6th International Conference on Mechanics and Materials in Design

Ponta Delgada/Azores, 26-30 July 2015

Indexing

ISI Web of Knowledge - 0 Citations

Other information

Authenticus ID: P-00K-MZE

Abstract (EN): The characterization of the in vitro culture evolution during the regenerative treatments by focusing on the cell and its environment, i.e., the scaffold and the trophic factors, requires cell level studies in order to define the necessary design parameters to produce a tissue engineered without setbacks. In general, a cell adheres to the substrate through focal adhesions, which are connected to the cytoskeleton through the actin fibers. In its turn, the actin fibers develop contractile forces in the internal body of the cell. Hence, in this way, the cells are able to sense the mechanical environment and respond to it by remodelling their focal adhesions and their cytoskeleton [1].

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 2