The role of angiotensin II in hypertension due to adenosine receptors blockade

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Morato, M (Author) FFUP; Sousa, T (Author) Other; Guimaraes, S (Author) Other; Moura, D (Author) FMUP; Albino Teixeira, A (Author) FMUP

Journal

Title: European Journal of Pharmacology

Vol. 455

Pages: 135-141

ISSN: 0014-2999

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 16 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-MBW

DOI: 10.1016/s0014-2999(02)02587-6

Abstract (EN): The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). Contractions of the mesenteric vasculature to angiotensin II, noradrenaline and potassium chloride were studied in DPSPX-induced hypertension. Male Wistar rats received infusions of saline or DPSPX (90 mug kg(-1) h(-1), i.p.) for 3 or 7 days. Blood pressure was determined by the tail-cuff method. On days 3 or 14, concentration-response curves were obtained on mesenteric arteries and veins. Plasma angiotensin II levels, measured by radioimmunoassay, were higher in DPSPX-hypertensive rats. The maximum contractile effect of angiotensin II was lower in vessels from DPSPX-hypertensive rats while that for noradrenaline was higher. Potassium chloride-induced contractions were larger in veins from DPSPX-hypertensive rats but similar in arteries, when compared with control rats. We conclude that raised angiotensin II levels and altered vascular reactivity are consistent with a renin-angiotensin-mediated hypertension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7