Multimilligram enantioresolution of low-solubility xanthonolignoids on polysaccharide chiral stationary phases using a solid-phase injection system

• Type: Article in International Conference Proceedings Book
• Date: 2006

Authors

Sousa, ME (Author) FFUP; Tiritan, ME (Author) Other; Belaz, KRA (Author) Other; Pedro, M (Author) Other; Nascimento, MSJ (Author) FFUP; Cass, QB (Author) Other; Pinto, MMM (Author) FFUP

Conference proceedings International

Title: JOURNAL OF CHROMATOGRAPHY A

Pages: 75-81

29th International Symposium on High Performance Liquid Separations and Related Techniques (HPLC 2005)

Stockholm, SWEDEN, JUN 26-30, 2005

Indexing

ISI Proceedings

ISI Web of Knowledge - 23 Citations

Scopus - 24 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-JMM

DOI: 10.1016/j.chroma.2005.12.071

Abstract (EN): Kielcorins are xanthonolignoids with protein kinase C inhibition and antitumor activities. Four racemates were enantioresolved at a multimilligram scale on tris-3,5-dimethylphenylcarbamate amylose phase using polar organic conditions as mobile phase. The low-solubility of these compounds conditioned the injection amount and consequently the productivity. A solid-phase injection system was developed to increase the production rate of the semipreparative process. The effects of the racemates and the related enantiomers on the in vitro growth of human breast cancer cell line MCF-7 were compared. Differences in their growth inhibitory activity were observed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7