Online Individualized Dose Estimation

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2009

Autores

Conceicao Rocha (Autor) Outra; Teresa Mendonca (Autor) FCUP; Eduarda E Silva (Autor) FCUP

Ata de Conferência Internacional

Título: WISP 2009: 6TH IEEE INTERNATIONAL SYMPOSIUM ON INTELLIGENT SIGNAL PROCESSING, PROCEEDINGS

Páginas: 275-279

6th IEEE International Symposium on Intelligent Signal Processing

Budapest, HUNGARY, AUG 26-28, 2009

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia electrotécnica, electrónica e informática

Outras Informações

ID Authenticus: P-003-SDF

DOI: 10.1109/wisp.2009.5286553

Abstract (EN): The development of automated individualized drug dosage regimens, namely in general anaesthesia environment, has been a subject of interest in the last decades. The use of continuous intravenous drug administration aims at, accurately, maintaining the system at a desired target effect concentration level. Different methods have been proposed for the design of individualized dosage regimens. In this study individual drug dose design is achieved through the characterization of transient initial response induced by a bolus administration of drug. This approach is based on the statistical analysis of the data using Walsh-Fourier spectral analysis which provides information about patient dynamics, allowing the on-line drug dose design using multiple linear least squares and quantile regression technics. The proposed methodology is illustrated in the case where the effect measured on the patient corresponds to the neuromuscular blockade (NMB) level and the drug to the muscle relaxant atracurium.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5