Metastatic breast cancer: mechanisms and opportunities for cytology

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Martins, D (Autor) Outra; Beca, F (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Cytopathology

Vol. 25

Páginas: 225-230

ISSN: 0956-5507

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Outras Informações

ID Authenticus: P-009-QSN

DOI: 10.1111/cyt.12158

Abstract (EN): Despite significant advances in diagnosis, surgical techniques, general patient care, and local and systemic adjuvant therapies, metastatic disease remains the most critical condition limiting the survival of patients with breast cancer. Therefore, the development of effective treatment against late-arising metastasis has become the centre of clinical attention and is one of the current challenges in cancer research. A deeper understanding of the metastatic cascade is fundamental, and the need for repetitive tumour assessments for the evaluation of tumour evolution is a relatively new practice in routine medical care. As such, fine needle aspiration cytology (FNAC) is ideally placed to monitor biological changes in metastasis that may affect treatment and response. As FNAC is a minimally invasive method, it can be performed repeatedly with relatively little trauma, and selective ancillary tests can be applied to FNAC specimens, including for tumour whose primary nature is known. Herein, we review how the linear and parallel models explain metastatic dissemination, thus influencing therapeutic and clinical decisions, and how cytology, together with immunocytochemistry and molecular analysis, can be a tool for routine clinical practice and clinical trials aimed at metastatic disease with a special emphasis on breast cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6