Endurance training prevents TWEAK but not myostatin-mediated cardiac remodelling in cancer cachexia

• Type: Article in International Scientific Journal
• Date: 2015

Authors

A. I. Padrão (Author) Other; D. Moreira-Gonçalves (Author) Other; P. A. Oliveira (Author) Other; C. Teixeira (Author) Other; A. I. Faustino-Rocha (Author) Other; L. Helguero (Author) Other; R. Vitorino (Author) Other; L. L. Santos (Author) Other; F. Amado (Author) Other; J. A. Duarte (Author) FADEUP; R. M. P. Ferreira (Author) Other

Journal

Title: Archives of Biochemistry and Biophysics

Vol. 567

Pages: 13-21

ISSN: 0003-9861

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 31 Citations

Scopus - 32 Citations

Scientific classification

FOS: Social sciences

Other information

Authenticus ID: P-00A-6VB

DOI: 10.1016/j.abb.2014.12.026

Abstract (EN): © 2015 Elsevier Inc. All rights reserved. Strategies to prevent tumour burden-induced cardiac remodelling that might progress to heart failure are necessary to improve patients' health outcomes and tolerability to cancer therapies. Exercise has been suggested as a measure to prevent cardiac damage; however, its effectiveness on regulating cardiac remodelling secondary to cancer was never addressed. Using an animal model of mammary tumorigenesis, we studied the impact of 35 weeks of endurance training on heart, focusing on the signalling pathways modulated by pro-inflammatory and wasting cytokines. The cardiac fibrosis and myofiber disorganization induced by tumour burden was paralleled by the increase of myostatin and TWEAK with the activation of signalling pathways involving Smad-3, NF-¿B, TRAF-6 and atrogin-1. The activation of Akt/mTOR was observed in heart from rats with tumours, for which contributed the extracellular matrix. Endurance training prevented the increase of serum and cardiac TWEAK promoted by cancer, as well as the activation of NF-¿B, TRAF6, atrogin-1 and p70S6K in heart. Data highlight the impact of exercise in the modulation of signalling pathways activated by wasting cytokines and the resulting outcomes on heart adaptation. Future studies focused on the cellular pathways underlying cardiac remodelling will assist in the development of exercise programs targeting cancer-related cardiac alterations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9