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Prenatal exposure to cocaine and enriched environment - Effects on social interactions

Title
Prenatal exposure to cocaine and enriched environment - Effects on social interactions
Type
Article in International Scientific Journal
Year
2006
Authors
Ana Magalhaes
(Author)
Other
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Teresa Summavielle
(Author)
Other
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Pedro Melo
(Author)
Other
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Rui Rosa
(Author)
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Maria Amelia Tavares
(Author)
FMUP
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Liliana De Sousa
(Author)
ICBAS
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Journal
Vol. 1074
Pages: 620-631
ISSN: 0077-8923
Publisher: Wiley-Blackwell
Scientific classification
FOS: Medical and Health sciences > Clinical medicine
Other information
Authenticus ID: P-004-P9K
Abstract (EN): Exposure to cocaine throughout gestation may produce several deleterious outcomes in the offspring that include effects on neurotransmitter systems and structure of the central nervous system. Such changes are most likely correlated with behavioral alterations. Environmental enrichment (EE) in early stages is a factor that affects structural and behavioral development. This article examines the effects, upon social interactions, of EE during the first month of life in rats prenatally exposed to cocaine. Wistar dams were subcutaneously exposed to 60 mg/kg of cocaine divided in two daily doses from gestational day (GD)8 to GD22. Pair-fed controls were given saline vehicle in the same protocol. Offspring were distributed to the different environments in four experimental groups. Group 1: offspring from dams prenatally exposed to cocaine as previously described and reared in EE from postnatal day (PND)1 to PND28; Group 2: pups from cocaine-exposed dams and reared in a standard environment (SE); Group 3: pups from pair-fed saline-exposed dams and reared in EE; Group 4: offspring from saline-exposed dams and reared in SE. On PND21, 24, and 28, rats were examined in several social behavioral categories (play fighting, social investigation, comfort behaviors, and solicitation to play) for 10 min. Animals reared in SE do not display any differences due to treatment in the behavioral categories analyzed. Control offspring reared in EE presented decreased play fighting, decreased solicitation to play, and decreased social investigation compared to the control SE group, while cocaine-exposed animals reared in EE did not present these variations. These results suggest that EE rearing may unmask hidden effects of prenatal cocaine exposure.
Language: English
Type (Professor's evaluation): Scientific
Contact: anam@ibmc.up.pt
No. of pages: 12
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