Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Carmo, H (Author) FFUP; de Boer, D (Author) Other; Remiao, F (Author) FFUP; Carvalho, F (Author) FFUP; dos Reys, LA (Author) Other; Bastos, MD (Author) FFUP

Journal

Title: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Vol. 811

Pages: 143-152

ISSN: 1570-0232

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 30 Citations

Scopus - 33 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-7NZ

DOI: 10.1016/j.chromb.2004.08.026

Abstract (EN): 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10