Results of the first 24 patients with Parkinson disease submitted to deep brain stimulation in Hospital S. João from 2002 a 2005 [Estimulação cerebral profunda na doença de Parkinson: Resultados nos primeiros 24 doentes tratados no Hospital São João de 2002 a 2005]

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Rosas, MJ (Author) Other; Mendes, A (Author) Other; Garrett, C (Author) FMUP; Linhares, P (Author) Other; Chamadoira, C (Author) Other; Basto, MA (Author) Other; Sousa, A (Author) Other; Fonseca, R (Author) Other; Vaz, R (Author) Other

Journal

Title: Sinapse

Vol. 5

Pages: 4-10

ISSN: 1645-281X

Publisher: Sociedade Portuguesa de Neurologia

Indexing

ISI Web of Knowledge

Scopus - 0 Citations

Other information

Authenticus ID: P-007-EKS

Abstract (EN): Introduction: Deep brain stimulation of the subthalamic nucleus (DBS) is a therapeutic option in patients with Parkinson Disease who have dyskinesias and motor fluctuations that dont improve with pharmacological treatment. This surgery has low morbidity and gives these patients a better motor function and quality of life. Aim: The authors report the results of the first 24 patients submitted to DBS in Hospital S. João - Porto from October 2002 to January 2005. Patients and methods: Targeting subthalamic nucleus is a stereotacic technique using image fusion between cerebral MRI and steretotacic CT scan, as well as intraoperative microrecordings and microstimulation of the subthalamic nucleus. We analyzed biographic data, duration of disease, UPDRS part 3 in on and off conditions before surgery and medication off/stimulation on after surgery, UPDRS part 4, cognitive evaluation ((MMSE; FAB; Frontal dysfunction tests, PM47, associative and visual tests), emotional tests (Beck Inventory for depression), quality of life (SF 36), medication (L-dopa) before and after surgery. Statistical methods: Mann-Whitney U test, t'test and correlation matrix. Statistical significance: p<0.05. Results: 72% male, median age 56.21 years old, duration of disease 14 years. Previous On: 13.88 (median), previous Off: 48.81 (median). Motor benefit after surgery 60.54% (median), L-dopa reduction 44.21%. In cognitive evaluation only verbal phonemic fluency decreased (p=0.03) not related with disartria. Depression wasn't different and the patients refered a better quality of life in physical scales in SF-36 (p=0.03). Adverse effects: intraventricular hemorrhage (one case) rejection of all neurostimulation device without infection (one case) bad positioned electrode (one case) immediate severe post surgery dyskinesias (3 cases).

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 7