INCREASED CEREBROSPINAL-FLUID DOPAMINE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVELS IN HUNTINGTONS-DISEASE - EVIDENCE FOR AN OVERACTIVE DOPAMINERGIC BRAIN TRANSMISSION

• Type: Article in International Scientific Journal
• Date: 1992

Authors

GARRETT, MC (Author) FMUP; SOARESDASILVA, P (Author) Other

Journal

Title: Journal of Neurochemistry

Vol. 58

Pages: 101-106

ISSN: 0022-3042

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-Q3M

DOI: 10.1111/j.1471-4159.1992.tb09283.x

Abstract (EN): Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) in the CSF of patients with Huntington's disease (HD) were measured by HPLC. CSF DA, DOPAC, and MHPG levels were found to be increased in HD patients. Levels of HVA, 5-HIAA, and NA in the CSF of HD patients did not differ from those of controls. Changes in CSF DA and DOPAC levels were consistent with previous findings of increased DA tissue content in some brain areas of patients with HD. These results suggest that CSF DOPAC levels could be a more reliable index of overactive dopaminergic brain systems in HD than CSF HVA levels.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6