Sartoryglabrins, Analogs of Ardeemins, from Neosartorya glabra

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Anake Kijjoa (Author) ICBAS; Sonia Santos (Author) Other; Tida Dethoup (Author) Other; Leka Manoch (Author) Other; Ana Paula Almeida (Author) Other; Maria Helena Vasconcelos (Author) FFUP; Artur Silva (Author) Other; Luis Gales (Author) ICBAS; Werner Herz (Author) Other

Journal

Title: Natural product communications

Vol. 6

Pages: 807-812

ISSN: 1934-578X

Publisher: SAGE

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 22 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-002-QRV

Abstract (EN): Chemical investigation of a collection of the fungus Neosartorya glabra from Thailand furnished sartoryglabins A-C (1a, 1b and 2) which are analogs of the reverse prenylated indole alkaloids known as (-) ardeemins. Structures of these compounds were established by NMR spectrometry and an X-ray analysis. Sartoryglabins A-C were evaluated for their in vitro growth inhibitory activity on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma). All the compounds exhibited strong to moderate activity against the MCF-7 cell line but weak or no activity against the NCI-H460 and A375-C5 cell lines. Sartoryglabin B was found to exhibit selectivity towards the MCF-7 cell line.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6