Hipocrates: A robust system for the control of neuromuscular blockade

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Mendonca, T (Author) FCUP; Lic, HM (Author) Other; Lago, P (Author) Other; Esteves, S (Author) Other

Journal

Title: Journal of Clinical Monitoring and Computing

Vol. 18

Pages: 265-273

ISSN: 1387-1307

Publisher: Springer Nature

Indexing

ISI Web of Knowledge

Scopus - 25 Citations

Other information

Authenticus ID: P-007-CKB

DOI: 10.1007/s10877-005-2222-4

Abstract (EN): Objective: Development of an automatic system (software package Hipocrates) for the control of neuromuscular blockade by continuous infusion of the non-depolarising types of muscle relaxant drugs presently used in anaesthesia, namely atracurium, cisatracurium, vecuronium and rocuronium. Methods. Hipocrates incorporates control strategies based upon classical, adaptive and robust control, as well as a wide range of noise reduction techniques and on-line adaptation to patient-specific characteristics. Therefore, the system provides strong robustness to inter- and intra- individual variabi lity of the patients responses or unexpected circumstances and adaptation to the individual requirements. Results. The control system is easy to set up and to use in a clinical environment. It consists of a portable PC computer, a Datex AS/3 NMT sensor and a B Braun compact perfusion pump. In the simulation mode the software package incorporates sophisticated generation of pharmacokinetic/pharmacodynamic models driven by simulated drug administration regimes (bolus, continuous infusion and a combination of both). Conclusions. Hipocrates is an advanced stand-alone application for the control of neuromuscular blockade with a friendly graphic interface. It has been extensively validated, and it can be used on patients undergoing surgery as well as for simulation studies. Therefore Hipocrates also provides an excellent environment for education and training purposes. © Springer Science + Business Media, Inc. 2005.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9