Modelling drugs' pharmacodynamic interaction during general anaesthesia: The choice of pharmacokinetic model

• Type: Article in International Conference Proceedings Book
• Date: 2006

Authors

Nunes, CS (Author) FCUP; Mendonca, TF (Author) FCUP; Antunes, L (Author) Other; Ferreira, DA (Author) Other; Lobo, F (Author) Other; Amorim, P (Author) Other

Conference proceedings International

Title: IFAC Proceedings Volumes (IFAC-PapersOnline)

Pages: 447-452

6th IFAC Symposium on Modeling and Control in Biomedical Systems, MCBMS 2006

Reims, 20 August 2006 through 22 August 2006

Indexing

ISI Web of Knowledge

Scopus - 12 Citations

Other information

Authenticus ID: P-007-ZJV

DOI: 10.3182/20060920-3-fr-2912.00080

Abstract (EN): The effect of drugs' interaction on the brain signal Bispectral Index (BIS) is of great importance for an anaesthesia control drug infusion system. In this study, two renowned pharmacokinetic (PK) models for propofol are compared, in order to evaluate its influence on the performance/predictably of a drug interaction model for BIS, considering data of 45 patients. The model was fitted per patient during anaesthesia induction, and tested for prediction under surgery. The results showed that the choice of PK model had influence on the overall performance. In the prediction phase, only one PK model presented good results with small errors. Copyright © 2006 IFAC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6