Control of individualized drug dosage regimens based on sparse measurements

• Type: Article in International Conference Proceedings Book
• Date: 2000

Authors

Mendonca, T (Author) FCUP; Lago, P (Author) FCUP; Eusebio, D (Author) Other

Conference proceedings International

Title: MODELLING AND CONTROL IN BIOMEDICAL SYSTEMS 2000

Pages: 273-277

4th IFAC Symposium on Modelling and Control in Biomedical Systems

KARLSBURG GREIFSWALD, GERMANY, MAR 30-APR 01, 2000

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

FOS: Engineering and technology > Electrical engineering, Electronic engineering, Information engineering

Other information

Authenticus ID: P-001-1X7

Abstract (EN): A number of different methods can be used for the design of individualized drug dosage regimens, based on measurements of the plasma concentration. This paper extends an adaptive control method coupled with Bayesian feedback to include all common routes and restrictions on the dosage regimens. Bolus administration and a piecewise constant administration (a model for the intravenous infusion) are both considered for pharmacokinetic systems of order n. Besides, a MATLAB package for the design of individualized drug dosage regimens was developed, both for clinical use and simulation purposes. The techniques are illustrated with the dosage of theophylline Copyright (C) 2000 IFAC.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5