Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population

• Type: Article in International Scientific Journal
• Date: 2014

Authors

al-mahruqi, sh (Author) Other; zadjali, f (Author) Other; beja-pereira, a (Author) FCUP; koh, cy (Author) Other; balkhair, a (Author) Other; al-jabri, aa (Author) Other

Journal

Title: Genetics and Molecular Biology

Vol. 37

Pages: 7-14

ISSN: 1415-4757

Publisher: Sociedade Brasileira de Genetica

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 1 Citation

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-009-8RS

DOI: 10.1590/s1415-47572014000100004

Abstract (EN): Polymorphisms in the regulatory region of the CCR5 gene affect protein expression and modulate the progress of HIV-1 disease. Because of this prominent role, variations in this gene have been under differential pressure and their frequencies vary among human populations. The CCR2V64I mutation is tightly linked to certain polymorphisms in the CCR5 gene. The current Omani population is genetically diverse, a reflection of their history as traders who ruled extensive regions around the Indian Ocean. In this study, we examined the CCR2-CCR5 haplotypes in Omanis and compared the patterns of genetic diversity with those of other populations. Blood samples were collected from 115 Omani adults and genomic DNA was screened to identify the polymorphic sites in theCCR5 gene and the CCR2V64I mutation. Four minor alleles were common: CCR5-2554T and CCR5-2086G showed frequencies of 49% and 46%, respectively, whereas CCR5-2459A and CCR5-2135C both had a frequency of 36%. These alleles showed moderate levels of heterozygosity, indicating that they were under balancing selection. However, the well-known allele CCR5 Delta 32 was relatively rare. Eleven haplotypes were identified, four of which were common: HHC (46%), HHE (20%), HHA (14%) and HHF*2 (12%).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8