Abstract (EN):
A three-way analytical methodology experimentally based on fluorescence excitation emission matrix (EEM) and in PARAFAC and TLD chemometric analysis was assessed for the quantification of verapamil drug in a tablet formulation. A standard addition procedure generates experimental information compatible with the chemometric data analysis model allowing the estimation of verapamil with a detection limit of about 0.04 mg/l using methanol as solvent. The structure of the verapamil EEM follows a trilinear model, but background signals (first- and second-order scatter bands) did not-a trilinear three-factor model is necessary to describe experimental datasets. The comparison of a three-factor PARAFAC model with a United States Pharmacopoeia (USP) standard chromatographic method showed similar results.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
11