PARAFAC and PARAFAC2 calibration models for antihypertensor Nifedipine quantification

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Leitao, JMM (Author) Other; da Silva, JCGE (Author) FCUP

Journal

Title: Analytica Chimica Acta

Vol. 559

Pages: 271-280

ISSN: 0003-2670

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 11 Citations

Scopus - 10 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-N8A

DOI: 10.1016/j.aca.2005.11.062

Abstract (EN): Two-way data structures were obtained by acquiring UV-vis spectra as function of the time of the alkaline hydrolysis reaction of the antihypertensor Nifedipine in dimethylsulfoxide (DMSO). Sets of three-way data structures were obtained from the analysis of solutions with different concentrations of Nifedipine generated by standard additions to DMSO, Nifedipine standard and a pharmaceutical formulation. PARAFAC and PARAFAC2 methods were used in the analysis of these multi-way data structures and calibration models were developed for Nifedipine quantification in pharmaceutical formulations. For all the three-way data structures a better model fit was found with the PARAFAC2 suggesting that the experimental data sets have deviations from trilinearity. The best concentrations estimations were found with the PARAFAC2 model in the analysis of a [concentration x time (s) x wavelength (nm)] three-way data structure which allows the quantification of Nifedipine in pharmaceutical formulations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10