PARAFAC2 and MCR-ALS quantification of Diltiazem antihypertensor based on a kinetic spectrophotometric methodology

• Type: Article in International Scientific Journal
• Date: 2007

Authors

leitao, jmm (Author) Other; da silva, jcge (Author) FCUP

Journal

Title: Chemometrics and Intelligent Laboratory Systems

Vol. 89

Pages: 90-96

ISSN: 0169-7439

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 19 Citations

Scientific classification

FOS: Engineering and technology > Electrical engineering, Electronic engineering, Information engineering

Other information

Authenticus ID: P-004-69J

DOI: 10.1016/j.chemolab.2007.06.003

Abstract (EN): A Diltiazem kinetic spectrophotornetric UV-Vis method, based on a reaction of the Diltiazem with hidroxylamine and a ferric salt, was used for the quantification of Diltiazem in different pharmaceutical formulations. This method is based on the acquisition of three-way data structures [wavelength (nm) x time (s) x concentration (mg/L)] followed by chemometric analysis by an appropriate PARAFAC2 or MCR-ALS second-order calibration model. The results obtained are compared with those obtained by direct determination, at maximum wavelength, and by the United States Pharmacopeia (USP) standard chromatographic method. For all the pharmaceutical formulations analysed good quantification results were found with PARAFAC2 and MCR-ALS second-order calibration models. For bulk drug analysis, detection limits of 6 and 2 mg/L, and for pharmaceutical formulations analysis, an average detection limit of 41 and 39 mg/L were found, respectively with PARAFAC2 and MCR-ALS.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7