Electroanalytical study of the antidepressant sertraline

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Nouws, HPA (Author) Other; Delerue Matos, C (Author) Other; Barros, AA (Author) FCUP; Rodrigues, JA (Author) FCUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 39 No. 5

Pages: 290-293

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 34 Citations

Scopus - 31 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-1N6

DOI: 10.1016/j.jpba.2005.02.040

Abstract (EN): A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 x 10(-6) and 1.20 x 10(-6) mol L-1. Limits of detection and quantification were found to be 1.5 x 10(-7) and 5.0 x 10(-7) mol L-1, respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4