mtDNAoffice: A software to assign human mtDNA macro haplogroups through automated analysis of the protein coding region

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Ines Soares (Author) Other; Antonio Amorim (Author) FCUP; Ana Goios (Author) Other

Journal

Title: Mitochondrion

Vol. 12

Pages: 666-668

ISSN: 1567-7249

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-002-3R2

DOI: 10.1016/j.mito.2012.08.003

Abstract (EN): We describe a fast, automated process to determine distances between mtDNA sequences allowing their subsequent clustering and haplogroup assignment that may increase the speed of data analysis and avoid human errors. In order to avoid complexities/ambiguities resulting from recurrence and insertion/deletion phenomena and thus improving evolutionary signal-to-noise ratio, protein coding sequences were compared using a vectorial representation method, and the corresponding genetic distance matrix was used for the construction of a neighbor-joining/UPGMA tree or an MDS graphic, which generally agrees with the consensus mtDNA phylogeny. mtDNAoffice software, detailed instructions and example files are freely available on the web at http://www.portugene.com/SupMat/setupmtDNAoffice.rar.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3