Variation in STR loci of the human myelin basic protein gene: North Portugal and Sao Tome e Principe

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Pereira, L (Author) Other; Gusmao, L (Author) FCUP; Prata, MJ (Author) FCUP; Mota, P (Author) Other; Trovoada, MJ (Author) Other; Amorim, A (Author) FCUP

Journal

Title: Human Biology

Vol. 72

Pages: 481-487

ISSN: 0018-7143

Publisher: Wayne State University Press

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-000-ZVE

Abstract (EN): Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and Sao Tome e Principe, Strong linkage disequilibrium between loci MBPB and MBPC was found, However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the Sao Tome population. Similarly, a difference in the frequency of base substitution G --> A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in Sao Tome. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7