Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Machado, JC (Author) FMUP; Pharoah, P (Author) Other; Sousa, S (Author) Other; Carvalho, R (Author) Other; Oliveira, C (Author) Other; Figueiredo, C (Author) Other; Amorim, A (Author) FCUP; Seruca, R (Author) FMUP; Caldas, C (Author) Other; Carneiro, F (Author) FMUP; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Gastroenterology

Vol. 121

Pages: 823-829

ISSN: 0016-5085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 348 Citations

Scopus - 387 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-T48

DOI: 10.1053/gast.2001.28000

Abstract (EN): Background & Aims: Interleukin (IL)-1 gene cluster proinflammatory polymorphisms have been associated with development of gastric atrophy and with increased risk of gastric carcinoma. We aimed to determine the association between IL-1 loci polymorphisms and increased risk of gastric carcinoma in samples from a Portuguese population, and to find whether there was any relationship with the histologic types of gastric carcinoma. Methods: In a case-control study including 220 controls and 152 patients with gastric carcinoma (intestinal, 76; diffuse, 37; and atypical, 39), both the IL-1B-511 biallelic polymorphism and the IL-1RN penta-allelic variable number of tandem repeats were genotyped. Results: We found a significant association between the IL-1 polymorphisms and increased risk for tumor development in patients with intestinal-type gastric carcinoma. A trend towards an increased risk of tumor development was also observed in patients with diffuse-type gastric carcinoma. No significant relationship was observed in patients with atypical carcinoma. Carriers of IL-1B-511T and IL-1RN*2 homozygotes had increased risk for developing intestinal-type gastric carcinoma with odds ratios of 2.7 (95% confidence interval [CI], 1.5-4.9) and 3.1 (95% CI, 1.5-6.5), respectively. Statistical analysis showed an interaction between the 2 loci with the risk conferred by the IL-1B-511T allele substantially increased (odds ratio, 9.0; 95% CI, 3.5-23.0) in individuals homozygous for the IL-1RN*2 allele. Conclusions: Our results provide further support to the association between IL-1 gene cluster proinflammatory polymorphisms and increased risk of gastric carcinoma. Furthermore, we found evidence pointing to the existence of a synergistic interaction between the IL-1B and IL-1RN polymorphisms.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7