Evaluating the forensic informativeness of mtDNA haplogroup H sub-typing on a Eurasian scale

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Pereira, L (Author) Other; Richards, M (Author) Other; Goios, A (Author) Other; Alonso, A (Author) Other; Albarran, C (Author) Other; Garcia, O (Author) Other; Behar, DM (Author) Other; Golge, M (Author) Other; Hatina, J (Author) Other; Al Gazali, L (Author) Other; Bradley, DG (Author) Other; Macaulay, V (Author) Other; Amorim, A (Author) FCUP

Journal

Title: Forensic Science International

Vol. 159

Pages: 43-50

ISSN: 0379-0738

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-004-KQE

DOI: 10.1016/j.forsciint.2005.06.008

Abstract (EN): The impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power is low in some Eurasian populations. We show that a small set (eight) of coding-region SNPs resolves a substantial proportion of the identical haplotypes, as defined by control-region variation alone. Moreover, this SNP set, while substantially increasing the discriminating efficiency in most Eurasian populations by roughly equal amounts, discloses population-specific profiles.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8