Chimpanzee homologous of human Y specific STRs - A comparative study and a proposal for nomenclature

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Gusmao, L (Author) Other; Gonzalez Neira, A (Author) Other; Alves, C (Author) Other; Lareu, M (Author) Other; Costa, S (Author) Other; Amorim, A (Author) FCUP; Carracedo, A (Author) Other

Journal

Title: Forensic Science International

Vol. 126

Pages: 129-136

ISSN: 0379-0738

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 47 Citations

Scopus - 55 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-000-PP6

DOI: 10.1016/s0379-0738(02)00046-4

Abstract (EN): Eleven Y specific microsatellites, previously studied in humans, were typed for fragment length and sequenced in chimpanzees (Pan troglodytes). The primers described by Ayub et al. (Nucleic Acids Res. 28, 2000, 2) for amplifying DYS434, DYS435, DYS436, DYS437, DYS438, DYS439 and those described by White et al. (Genomics, 57,1999,433) for GATA A10, A7.1, A7.2, C4, and H4, were used to amplify DNA samples from chimpanzees. Primers described for Y GATA A4 were found to amplify the same region as reported for DYS439. Moreover, the GATA A4 forward primer only matches the repeat flanking region in 14 of the 28 bp, being responsible for a very weak amplification. Therefore, this system was not included in this study. The analysis of the repeat and sequence structure observed in chimpanzee and human Y chromosomes allowed evolutionary comparisons as well as the basis for improving Y STR nomenclature and therefore, a unified nomenclature for these novel STRs is proposed to the scientific community following ISFG recommendations.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8