MUC6 gene polymorphism in healthy individuals and in gastric cancer patients from northern Portugal

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Garcia, E (Author) Other; Carvalho, F (Author) Other; Amorim, A (Author) FCUP; David, L (Author) FMUP

Journal

Title: Cancer Epidemiology Biomarkers and Prevention

Vol. 6

Pages: 1071-1074

ISSN: 1055-9965

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 24 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-001-A61

Abstract (EN): Mucins exhibit a high degree of genetic polymorphism because of the presence of a variable number of tandem repeats, The aims of this work were to describe the MUC6 gene polymorphism in the Portuguese population and to evaluate whether MUC6 gene polymorphism was involved in individual susceptibility to gastric cancer development, as observed previously for the MUC1 gene, We found that the 10 alleles identified in the population of blood donors (n = 376), by Southern blot analysis, were also found in gastric cancer patients (n = 157), However, significant differences in allelic frequencies between the two populations were observed for 4 of the 10 alleles, in agreement with those described previously for the MUC1 gene; the largest allele was more frequent in blood donors, and smaller alleles were more frequent in gastric cancer patients, Our results suggest that MUC6 gene polymorphism is involved in the predisposition to gastric carcinoma development.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4