Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

• Type: Article in International Scientific Journal
• Date: 2005

Authors

Pereira, L (Author) Other; Goncalves, J (Author) Other; Goios, A (Author) Other; Rocha, T (Author) Other; Amorim, A (Author) FCUP

Journal

Title: International Journal of Andrology

Vol. 28

Pages: 241-247

ISSN: 0105-6263

Publisher: Blackwell

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 30 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-23V

DOI: 10.1111/j.1365-2605.2005.00539.x

Abstract (EN): A mitochondrial DNA (mtDNA) haplogroup association study carried out in 101 southern Portuguese males with oligozoospermia showed to be negative when comparing with a geographically matching control sample. Misleading positive association signs were however obtained when using other control samples from the same country. This shows that mtDNA population substructure can also introduce spurious signs in haplogroup association studies, as previously reported for Y-chromosome. However, our data do not exclude the probability that a particular mtDNA mutation contributes significantly to the reduction of sperm production, but indeed precludes the hypothesis of a significant association between such a mutation and specific haplogroup.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7